2,4-Diaminotoluene 2,4-二氨基甲苯

CAS 95-80-7 MFCD00007804

化学结构图

95-80-7
SMILES: Cc1ccc(N)cc1N

化学属性

Mol. FormulaC7H10N2
Mol. Weight122.17
Boiling Point292°C(lit.)
Melting Point97.0 to 100.0 deg-C
Flash Point169°(336°F)
TSCAYes
Solubility50 G/L (25 ºC)
Stability对湿度敏感
Density1.107

别名和识别编码

Chemical Name2,4-Diaminotoluene
CAS Number95-80-7
Synonym 4-Methylbenzene-1,3-diamine {LY} 4-Methylbenzene-1,3-diamine {} {LY} 4-Methylbenzene-1,3-diamine {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID87566860
EC Number202-453-1
Beilstein Registry Number13,124
MDL NumberMFCD00007804
Reaxys-RN2205839
Chemical Name Translation2,4-二氨基甲苯
Wiswesser Line NotationZR CZ D1
LabNetwork Molecule IDLN00227129
InChIInChI=1S/C7H10N2/c1-5-2-3-6(8)4-7(5)9/h2-4H,8-9H2,1H3
Canonical SMILESNC1=CC=C(C)C(N)=C1
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} 2002/61/EC, All alphabetical sorted, Alpha Sort, Alphabetical Index of Analytical Standards, Amines, Analytical Standards, Aromatics, Aryl Amines MAK III, Category 2, Chemical Class, Chromatography, Colors, Environmental Standards, European Community: ISO, DIN and DL 152, M, META - METH, Method and Regulation Specific, Oeko-Tex Standard 100, Volatiles/ Semivolatiles, 分析/色谱
  • {SNA} 2002/61/EC, Additional Standards, All alphabetical sorted, Alpha Sort, Amines, An

产品应用

  • 是有机合成原料之一,可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑

相关文献及参考

  • Short: EINECS
  • Benigni, R., et al.: Chem. Rev., 105, 1767 (2005),
  • Short: IV/20C
  • Beilstein:13,124
  • Benigni, R., et al.: Environ. Mol. Mutagen., 50, 152 (2009),
  • Franke, R., et al.: Carcinogenesis, 22, 1561 (2001),

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311
  • H312 Harmful in contact with skin 皮肤接触有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H350 May cause cancer 可能致癌
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T,N T;N
RTECSXS9625000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P312+P361+P364
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P308+P313
  • P337+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger {} {} {TCI}
UN Number 1709 UN 1709 6.1/PG 3 UN1709
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R48/22
  • R45 May cause cancer 可能致癌
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R51/53
  • R36 Irritating to eyes 刺激眼睛
Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9000 mg/kg/36W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   29,1137,1969

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5030 mg/kg/84W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-162,1979

TYPE OF TEST            : TD

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   70,453,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2100 mg/kg/90W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,1107,197

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(1-2),149,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.  (Berlin,
   Ger.)  V.1-22, 1905-21. For publisher information, see REXMAS.
   Volume(issue)/page/year: 17,59,1915

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.  (Berlin,
   Ger.)  V.1-22, 1905-21. For publisher information, see REXMAS.
   Volume(issue)/page/year: 17,59,1915

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   XPHBAO U.S. Public Health Service, Public Health Bulletin.  (Washington

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 15200 mmol/L/3D
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,181,1977

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 135,115,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 76,291,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 127,107,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,2233,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,763,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,753,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   7,29,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

Restrict 危险品

其他信息

  • 刺激数据:皮肤- 兔子 500 毫克/ 24小时 轻度; 眼- 兔子 100 毫克/ 24小时 中度
  • 外观性质:无色针状或菱形结晶。
  • Acros Organics:1-甲基-2,4-苯二胺 2,4-Diaminotoluene, 98%(95-80-7)
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂、酸类分开存放
  • 急性毒性:腹抢- 大鼠 LD50: 325 毫克/ 公斤; 腹腔- 小鼠 LD50: 480 毫克/ 公斤
  • 图谱信息:2,4-二氨基甲苯(95-80-7)红外图谱(IR2) 2,4-二氨基甲苯(95-80-7)核磁图( 13 CNMR) 2,4-二氨基甲苯(95-80-7)质谱(MS) 2,4-二氨基甲苯(95-80-7)核磁图( 1 HNMR) 2,4-二氨基甲苯(95-80-7)红外图谱(IR1)
  • 类别:有毒物品
  • 溶于水、乙醇、乙醚。
  • MSDS 信息:2,4-二氨基甲苯(95-80-7).msds
  • 色指数:76035
  • 海关编码:29331990
  • 用途一:用于制取TDI、硫化染料、碱性染料、分散染料、医药中间体及其他有机合成的中间体
  • 用途二:有机合成中间体。用于生产甲苯二异氰酸酯,染料毛皮黑DB、硫化黄棕5G、硫化黄棕6G、硫化红棕B3R等。制成的染料可使皮毛、头发直接氧化成黑色。
  • MOL 文件:95-80-7.mol
  • 灭火剂:泡沫、雾状水、二氧化碳、砂土
  • 方法一:由对硝基甲苯用混酸硝化得2,4-二硝基甲苯,然后用铁粉还原得粗品,再经浓缩、蒸馏得成品。原料消耗定额:对硝基甲苯1600kg/t、硫酸(98%)1616kg/t、硝酸(98%)760kg/t、铁粉(90%)2700kg/t。
  • 2,4-二氨基甲苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80043125 2,4-二氨基甲苯;2,4-甲苯二胺;2,4-叨二胺; 4-甲基间苯二胺 50g 23元 2011/08/23 80043126 2,4-二氨基甲苯;2,4-甲苯二胺;2,4-叨二胺; 4-甲基间苯二胺 100g 45.6元 2011/04/16 D0123 2,4-二氨基甲苯 2,4-Diaminotoluene 25G 175元
  • TCI Shanghai:2,4-二氨基甲苯 2,4-Diaminotoluene,>;98.0%(GC)(T)(95-80-7)
  • F:8-10-23
  • Alfa Aesar:2,4-二氨基甲苯,98% 2,4-Diaminotoluene, 98%(95-80-7)
  • 下游产品:2,4-二氯甲苯 --> 2,4-二氯苯甲酸 --> 1,4-二氨基蒽醌 --> 1,4-二氨基蒽醌隐色体 --> 硫化黄GC --> 硫化褐 10号 --> 硫化红棕B3R --> 硫化红6 --> 硫化黄棕6G --> 硫化黄2 --> 2,4-二溴苯甲酸
  • 毒性分级:高毒
  • 用途三:是有机合成原料之一,可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑
  • 可燃性危险特性:明火可燃;高热分解有毒氮氧化物烟雾
  • 上游原料:硫酸 --> 4-硝基甲苯 --> 2,4-二硝基甲苯
  • Sigma Aldrich:95-80-7(sigmaaldrich)

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