L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester 奥利司他

CAS 96829-58-2 MFCD05662360

化学结构图

96829-58-2
SMILES: CC(C)C[C@@H](NC=O)C(=O)O[C@@H](C[C@H]1OC(=O)[C@@H]1CCCCCC)CCCCCCCCCCC |&1:4,11,13,17|

化学属性

Mol. FormulaC29H53NO5
Mol. Weight496
Melting Point43-47

别名和识别编码

Chemical NameL-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
Synonym ()-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647 (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)​-​1-​[[(2S,3S)​-​3-​hexyl-​4-​oxo-​2-​oxetanyl]​methyl]​dodecyl ester, Ro-18-0647 N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester Orlistat Ro-18-0647
MDL NumberMFCD05662360
PubChem Substance ID135727048
CAS Number96829-58-2
Reaxys-RN3658031
Merck Number6869
Chemical Name Translation奥利司他
Beilstein Registry Number3658031
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分类

  • {SA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, Lipase, Pancreatic, Lipid Metabolism (Obesity), O, Obesity Research, Roche
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, Lipase, Pancrea
  • {SNA} Approved Therapeutics/Drug Can

相关文献及参考

  • [2]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10(3). pii: E353.
  • [3]. Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004;(3):CD004094.
  • Lucas, K.H., et al., Orlistat-a novel weight loss therapy. Ann. Pharmacother. 35 , 314-328, (2001)
  • Merck 14 ,6869
  • [1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov;35(11):1103-8.
  • [1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov;35(11):1103-8.
  • [2]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10(3). pii: E353.
  • [3]. Padwal R, et al. Lon

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
RTECSOH3167600
Storage condition 0-10 0-10°C
GHS Symbol

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Lipase, Pancreatic - L to O
  1. Medical Research Areas
  2. Metabolism
  3. Fatty Acid Synthase (FASN)  (脂肪酸合成酶)

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