OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.

CAS 98293-88-0 MFCD98293880

化学结构图

98293-88-0
SMILES: N#Cc1cc(-c2ccncc2)c(/C=N/N)[nH]c1=O

化学属性

Mol. Weight239.23276
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameOK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.
FormulaC12H9N5O
Synonym OK1035; OK 1035; OK-1035.
IUPAC Name(E)-2-(hydrazonomethyl)-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
InChIKeyKJRKRHGTENMKAI-FRKPEAEDSA-N
InChIInChI=1S/C12H9N5O/c13-6-9-5-10(8-1-3-15-4-2-8)11(7-16-14)17-12(9)18/h1-5,7H,14H2,(H,17,18)/b16-7+
Canonical SMILESN#CC1=CC(C2=CC=NC=C2)=C(/C=N/N)NC1=O
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产品应用

  • OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. DNA Damage
  3. DNA-PK
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. DNA-PK

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