Debio-0932 (CUDC305)
CAS 1061318-81-7 MFCD161318817
化学结构图
SMILES: CNc1nccc(-c2ncc(C(=O)N[C@H](CN)Cc3ccc(Cl)cc3Cl)s2)n1
化学属性
| Mol. Weight | 442.5776 |
|---|---|
| Appearance | white to off-white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Debio-0932 (CUDC305) |
|---|---|
| Formula | C22H30N6O2S |
| Synonym | Debio0932; Debio-0932; Debio 0932; CUDC305; CUDC-305; CUDC 305. |
| IUPAC Name | 2-((6-(dimethylamino)benzo[d][1,3]dioxol-5-yl)thio)-1-(2-(neopentylamino)ethyl)-1H-imidazo[4,5-c]pyridin-4-amine |
| InChIKey | PFYLLYYLCPZDMP-LBPRGKRZSA-N |
| InChI | InChI=1S/C18H18Cl2N6OS/c1-22-18-23-5-4-14(26-18)17-24-9-15(28-17)16(27)25-12(8-21)6-10-2-3-11(19)7-13(10)20/h2-5,7,9,12H,6,8,21H2,1H3,(H,25,27)(H,22,23,26)/t12-/m0/s1 |
| Canonical SMILES | O=C(C1=CN=C(C2=NC(NC)=NC=C2)S1)N[C@@H](CC3=CC=C(Cl)C=C3Cl)CN |
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产品应用
- Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.
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