GNE-900

CAS 1200126-26-6 MFCD300126266

化学结构图

1200126-26-6
SMILES: N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12

化学属性

Mol. Weight367.45
Appearance Solid powder
SolubilitySoluble in DMSO, not soluble in water.

别名和识别编码

Chemical NameGNE-900
FormulaC23H21N5
Synonym GNE900; GNE-900; GNE 900.
IUPAC Name3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile
InChIKeyPPYHOOZGDDPLKM-UHFFFAOYSA-N
InChIInChI=1S/C23H21N5/c24-12-19-11-20-21-10-18(13-26-23(21)27-22(20)14-25-19)17-6-4-16(5-7-17)15-28-8-2-1-3-9-28/h4-7,10-11,13-14H,1-3,8-9,15H2,(H,26,27)
Canonical SMILESN#CC1=NC=C2C(C3=CC(C4=CC=C(CN5CCCCC5)C=C4)=CN=C3N2)=C1
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产品应用

  • GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. (Mol Cancer Ther; 12(10); 1968-80).

安全信息

Storage condition 0 – 4 C for short term (weeks to 1 month) or -20 C for long terms (months to years).

系列性分类

  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. ATM/ATR

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