(E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione (E)-5-((5-(4-氟苯基)呋喃-2-基)亚甲基)噻唑烷-2,4-二酮

CAS 1218777-13-9 MFCD318777139

化学结构图

1218777-13-9
SMILES: O=C1NC(=O)/C(=C\c2ccc(-c3ccc(F)cc3)o2)S1

化学属性

Mol. Weight289.28
Appearance Solid powder
SolubilitySoluble in DMSO, not soluble in water or ethanol.

别名和识别编码

Chemical Name Translation(E)-5-((5-(4-氟苯基)呋喃-2-基)亚甲基)噻唑烷-2,4-二酮
Chemical Name(E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
FormulaC14H8FNO3S
Synonym CAY10505; CAY 10505; CAY10505
IUPAC Name(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
InChIKeyUFBTYTGRUBUUIL-KPKJPENVSA-N
InChIInChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
Canonical SMILESO=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2
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产品应用

  • CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. PI3K

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