Aurothioglucose [USP]

CAS 12192-57-3 MFCD12192573

化学结构图

12192-57-3
SMILES: OC[C@H]1OC2[SH-][Au+]O[C@@H]2[C@@H](O)[C@@H]1O

化学属性

Mol. Weight392.18 (anhydrous basis)
Mol. FormulaC6H11AuO5S · xH2O

别名和识别编码

Synonym Gold thioglucose SKF 10056 Aurothioglucose Auromyose (1-D-Glucosylthio)gold Aurumine 1-Thio-D-glucopyranose, gold complex Gold, (D-glucopyranosylthio)- (D-Glucopyranosylthio)gold Solganal B (1-Thio-D-glucopyranosato)gold Gold thioglucose; (1-D-Glucosylthio)gold; (1-Thio-D-glucopyranosato)gold; (alpha-D-Glucopyranosylthio)gold Aurotan 1-Aurothio-D-glucopyranose Thioglucose d'or Oronol Authron 1-Thio-glucopyranose, monogold(1+) salt GTG Gold thioglucose Solganal Solganol Solganal Aureotan Solganol Glysanol B Brenol 1-Thio-D-glucopyranose, monogold(1+) salt Romosol
PubChem Substance ID24724383
CAS Number12192-57-3
EC Number235-365-7
Chemical NameAurothioglucose hydrate
InChIKeyMSCUYDPRQMSUFW-BMZZJELJSA-N
Wiswesser Line NotationT6OTJ BS-AU-H CQ DQ EQ F1Q
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {SNA} AN-AZ, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • AN-AZ, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors

相关文献及参考

  • Stallings-Mann, M., et al., A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells Cancer Res. 66 , 1767-1774, (2006) 摘要
  • Merck 14 ,883

安全信息

GHS Symbol
Precautionary statements
  • P342+P311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - tumors
REFERENCE :
   RFECAC Revue Francaise d'Etudes Cliniques et Biologiques.  (Paris, France)
   V.1-14, 1956-69.  For publisher information, see BIMDB3.
   Volume(issue)/page/year: 11,828,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 3,37,1959

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Musculoskeletal - tumors
REFERENCE :
   RFECAC Revue Francaise d'Etudes Cliniques et Biologiques.  (Paris, France)
   V.1-14, 1956-69.  For publisher information, see BIMDB3.
   Volume(issue)/page/year: 13,40,1968

RTECSMD6475000
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Spinal Cord - other degenerative changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,223,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2700 ug/kg/4W-I
TOXIC EFFECTS :
   Liver - jaundice, cholestatic
REFERENCE :
   JRHUA9 Journal of Rheumatology.  (920 Yonge St., Suite 608, Toronto, Ont.,
   Canada)  V.1-    1974-  Volume(issue)/page/year: 11,843,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EMSUA8 Experimental Medicine and Surgery.  (Brooklyn, NY)  V.1-29, 1943-71.
   Suspended.  Volume(issue)/page/year: 3,146,1945

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SAVEAB Sammlung von Vergiftungsfaellen.  (Berlin, Germany)  V.1-13, 1930-44;
   V.14, 1952-54.  For publisher information, see ARTODN.
   Volume(issue)/page/year: 10,101A,1939

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 800 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   78,845,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 124,1190,1967

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S22 Do not breathe dust 不要吸入粉尘;
Hazard Codes Xn
Risk Statements
  • R42/43

系列性分类


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