Candoxatril

CAS 123122-55-4 MFCD23122554

化学结构图

123122-55-4
SMILES: COCCOC[C@@H](CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(=O)OC1C=C2CCCC2=CC=1 |&1:6,16,19|

化学属性

Mol. Weight515.64
Mol. FormulaC29H41NO7

别名和识别编码

CAS Number123122-55-4
Chemical NameCandoxatril
Synonym cis-4-[[[1-[(2S)-3-[(2,3-Dihydro-1H-inden-5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl]carbonyl]amino]cyclohexanecarboxylic Acid UK 79300
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Chiral Reagents
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Neutral endopeptidase inhibitor. Used in treatment of congestive heart failure.

相关文献及参考

  • [2]. M Aleksinskaya, et al. Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model. Bmc Pharmacology & Toxicology , 2013 , 14 (1) :1-2.
  • Kimmelstiel, C.D., et al.: Cardiology, 87, 46 (1996),
  • Motwani, J.G., et al.: Clin. Pharmacol. Ther., 54, 661 (1993),
  • [1]. Bevan EG, et al. Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. J Hypertens. 1992 Jul;10(7):607-13.
  • [1]. Bevan EG, et al. Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. J Hypertens. 1992 Jul;10(7):607-13.
  • [2]. M Aleksinskaya, et al. Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model. Bmc Pharmacology & Toxicology , 2013 , 14 (1) :1-2.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Neprilysin  (脑啡肽酶)

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