2-(4-(2-Methylpyridin-4-Yl)Phenyl)-N-(4-(Pyridin-3-Yl)Phenyl)Acetamide 2-(4-(2-甲基吡啶-4-基)苯基)-N-(4-(吡啶-3-基)苯基)乙酰胺
CAS 1243243-89-1 MFCD343243891
化学结构图
SMILES: Cc1cc(-c2ccc(CC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1
化学属性
| Mol. Weight | 379 |
|---|---|
| Appearance | White to off-white solid powder |
| Solubility | Soluble in DMSO, not in water |
| Mol. Formula | C25H21N3O |
别名和识别编码
| Chemical Name Translation | 2-(4-(2-甲基吡啶-4-基)苯基)-N-(4-(吡啶-3-基)苯基)乙酰胺 |
|---|---|
| Chemical Name | 2-(4-(2-Methylpyridin-4-Yl)Phenyl)-N-(4-(Pyridin-3-Yl)Phenyl)Acetamide |
| PubChem Substance ID | 57519544 |
| InChI | InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29) |
| Synonym | 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide C59 compound Wnt-C59 WntC59; Wnt-C 59; Wnt-C59 |
| LabNetwork Molecule ID | LN00218078 |
| Formula | C25H21N3O |
| IUPAC Name | 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide |
| InChIKey | KHZOJCQBHJUJFY-UHFFFAOYSA-N |
| Canonical SMILES | O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3 |
| MDL Number | N/A |
| CAS Number | 1243243-89-1 |
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产品应用
- Wnt-C59 is a potent porcupine (PORCN) inhibitor. Wnt-C59 inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity. In mice, Wnt-C59 displayed good bioavailability, as once daily oral administration was sufficient to maintain blood concentrations well above the IC(50). C59 blocked progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes. Porcupine (PORCN) is a membrane bound O-acyltransferase that is required for Wnt palmitoylation, secretion, and biologic activity.
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