INCB3344 INCB3344

CAS 1262238-11-8 MFCD362238118

化学结构图

1262238-11-8
SMILES: CCOC1CN(C2CCC(O)(c3ccc4c(c3)OCO4)CC2)CC1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1

别名和识别编码

PubChem Substance ID10008367
InChIInChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21?,22-,25-,28?/m0/s1
Synonym INCB3344
Chemical NameINCB3344
Chemical Name TranslationINCB3344
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信息真实价格透明    资金保障    专业采购外包团队在线服务   
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相关文献及参考

  • [2]. Brodmerkel CM, et al. Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. J Immunol. 2005 Oct 15;175(8):5370-8.
  • [3]. Chan CT, et al. Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice. Hypertension. 2012 Nov;60(5):1207-12.
  • [4]. Dansereau MA, et al. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. J Neurochem. 2008 Jul;106(2):757-69.
  • [5]. Zhao W, et al. Enrichment of Ly6Chi monocytes by multiple GM-CSF injections with HBV vaccine contributes to viral clearance in a HBV mouse model. Hum Vaccin Immunother. 2017 Dec 2;13(12):2872-2882.
  • [6]. Aye-Mon A, et al. CCR2 upregulation in DRG neurons plays a crucial role in gastric hyperalgesia associated with diabetic gastropathy. Mol Pain. 2018 Jan-Dec;14:1744806917751322.
  • [7]. Cassini MF, et al. Mcp1 Promotes Macropha

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