GSK2578215A 5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺

CAS 1285515-21-0 MFCD385515210

化学结构图

1285515-21-0
SMILES: O=C(Nc1cccnc1)c1cc(-c2ccnc(F)c2)ccc1OCc1ccccc1

化学属性

Mol. Weight399
Appearance Solid powder
SolubilitySoluble in DMSO, not in water
Mol. FormulaC24H18FN3O2

别名和识别编码

Chemical Name Translation5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺
Chemical NameGSK2578215A
FormulaC24H18FN3O2
Synonym GSK2578215A; GSK-2578215A; GSK 2578215A.
IUPAC Name2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide
InChIKeyWCIGMFCFPXZRMQ-UHFFFAOYSA-N
InChIInChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
Canonical SMILESO=C(NC1=CC=CN=C1)C2=CC(C3=CC(F)=NC=C3)=CC=C2OCC4=CC=CC=C4
MDL NumberN/A
CAS Number1285515-21-0
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产品应用

  • GSK2578215A is a potent and highly selective LRRK2 kinase inhibitor. GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson's disease, and its inhibition opens potential new therapeutic options. GSK2578215A induces mitochondrial fragmentation of an early step preceding autophagy. GSK2578215A induced oxidative stress as evidenced by the accumulation of 4-hydroxy-2-nonenal in SH-SY5Y cells.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P317
  • P330 Rinse mouth. 漱口
Packing GroupIII

系列性分类

  1. Medical Research Areas
  2. Autophagy
  3. LRRK2

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