(8S,10S,13S,14S,16R,17R)-17-Hydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-6,7,8,10,12,13,14,15,16,17-Decahydro-3H-Cyclopenta[a]Phenanthren-3-One (8S,10S,13S,14S,16R,17R)-17-羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊并[a]菲-3-酮

CAS 13209-41-1 MFCD13209411

化学结构图

13209-41-1
SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CO |&1:1,3,4,13,18,20|

化学属性

Mol. Weight356.46
Mol. FormulaC22H28O4

别名和识别编码

CAS Number13209-41-1
Chemical Name(8S,10S,13S,14S,16R,17R)-17-Hydroxy-17-(2-Hydroxyacetyl)-10,13,16-Trimethyl-6,7,8,10,12,13,14,15,16,17-Decahydro-3H-Cyclopenta[a]Phenanthren-3-One
Synonym (16?)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione 17?,21-Dihydroxy-16?-methylpregna-1,4,9(11)-triene-3,20-dione
Chemical Name Translation(8S,10S,13S,14S,16R,17R)-17-羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊并[a]菲-3-酮
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • A related intermediate of Prednisolone (P703740).

相关文献及参考

  • [2]. Dillingham BC, et al. VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis. Cell Mol Neurobiol. 2015 Apr;35(3):377-387.
  • [3]. Heier CR, et al. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy. Life Sci Alliance. 2019 Feb 11;2(1). pii: e201800186.
  • Cimarusti, C., et al.: J. Med. Chem., 19, 721 (1976),
  • Popper, T., et al.: J. Steroid Biochem., 27, 837 (1987),
  • [1]. Heier CR, et al. VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects. EMBO Mol Med. 2013 Oct;5(10):1569-85.
  • [1]. Heier CR, et al. VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects. EMBO Mol Med. 2013 Oct;5(10):1569-85.
  • [2]. Dillingham BC, et al. VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimm

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)
  1. Medical Research Areas
  2. Metabolism
  3. Mineralocorticoid Receptor  (盐皮质激素受体)

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