CID 53469059 1-(5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)-4-氟吲哚啉-1-基)-2-(6-甲基吡啶-2-基)乙酮
CAS 1337532-29-2 MFCD437532292
化学结构图
SMILES: Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
化学属性
| Mol. Weight | 416 |
|---|---|
| Appearance | white to light yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
| Mol. Formula | C23H21FN6O |
别名和识别编码
| Chemical Name Translation | 1-(5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)-4-氟吲哚啉-1-基)-2-(6-甲基吡啶-2-基)乙酮 |
|---|---|
| Chemical Name | GSK2656157 |
| PubChem Substance ID | 53469059 |
| InChI | InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27) |
| Synonym | GSK2656157 GSK2656157; GSK 2656157; GSK-2656157. |
| LabNetwork Molecule ID | LN01309971 |
| Formula | C23H21FN6O |
| IUPAC Name | 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone |
| InChIKey | PRWSIEBRGXYXAJ-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3F)=O)=N1 |
| MDL Number | |
| CAS Number | 1337532-29-2 |
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产品应用
- GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC50 of 0.9 nM. It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. GSK2656157 inhibits PERK activity in cells with an IC50 in the range of 10-30 nM as shown by inhibition of stress-induced PERK autophosphorylation, eIF2α substrate phosphorylation, together with corresponding decreases in ATF4 and CHOP proteins in multiple cell lines. Oral administration of GSK2656157 to mice shows a dose- and time-dependent pharmacodynamic response in pancreas as measured by PERK auto-phosphorylation.
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