Lobaplatin 乐铂

CAS 135558-11-1 MFCD35558111

化学结构图

135558-11-1
SMILES:

化学属性

Mol. FormulaC9H18N2O3Pt
Mol. Weight397.33

别名和识别编码

Chemical NameLobaplatin
Chemical Name Translation乐铂
Chemicalbook IDCB4741909
FormulaC9H18N2O3Pt
Synonym D19466; D-19466; Lobaplatin.
IUPAC Namecis-[(1R*,2R*)-1,2-Cyclobutanebis(methylamino)-N,N'][(2S)-2-hydroxypropanoato(2-)-O1,O2]platinum
InChIKeyRLXPIABKJFUYFG-UHFFFAOYSA-M
InChIInChI=1S/C6H14N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-6H,1-4,7-8H2;2H,1H3,(H,5,6);/q;-1;+2/p-1
Canonical SMILESCC([O-]1)C([O-][Pt]21[NH2+]CC(CC3)C3C[NH2+]2)=O.
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产品应用

  • Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration. (source: Expert Opin Investig Drugs. 2001 Jan;10(1):119-28.).

系列性分类

  1. Medical Research Areas
  2. Cell Cycle
  3. c-Myc

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