AMG-3969 AMG-3969游离态

CAS 1361224-53-4 MFCD461224534

化学结构图

1361224-53-4
SMILES: CC#CC1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1

别名和识别编码

PubChem Substance ID73053709
InChIInChI=1S/C21H20F6N4O3S/c1-2-3-16-13-30(35(33,34)17-8-9-18(28)29-12-17)10-11-31(16)15-6-4-14(5-7-15)19(32,20(22,23)24)21(25,26)27/h4-9,12,16,32H,10-11,13H2,1H3,(H2,28,29)/t16-/m0/s1
Synonym 2-(4-(4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol AMG-3969
Chemical Name TranslationAMG-3969游离态
Chemical NameAMG-3969
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相关文献及参考

  • J Med Chem. 2014 Apr 10;57(7):3094-116.
  • [2]. Nishimura N, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
  • [3]. St Jean DJ Jr, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J Med Chem. 2014 Jan 23;57(2):325-38.
  • J Med Chem. 2014 Apr 10;57(7):3094-116.
  • [1]. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.
  • [1]. Lloyd DJ, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 2013 Dec 19;504(7480):437-40.
  • [2]. Nishimura N, et al. Small molecule disruptors of the glucokinase-glucokinase regu

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Glucokinase  (葡萄糖激酶)

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