Methyl 2-Benzamido-1-(3-Phenylpropyl)-1H-Benzo[D]Imidazole-5-Carboxylate 2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[d]咪唑-5-羧酸甲酯

CAS 1374601-40-7 MFCD474601407

化学结构图

1374601-40-7
SMILES: COC(=O)c1ccc2c(c1)nc(NC(=O)c1ccccc1)n2CCCc1ccccc1

化学属性

Mol. Weight413.47
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[d]咪唑-5-羧酸甲酯
Chemical NameMethyl 2-Benzamido-1-(3-Phenylpropyl)-1H-Benzo[D]Imidazole-5-Carboxylate
FormulaC25H23N3O3
Synonym BRD4770; BRD-4770; BRD 4770.
IUPAC Namemethyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate
InChIKeyUCGWYCMPZXDHNR-UHFFFAOYSA-N
InChIInChI=1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29)
Canonical SMILESO=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC
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产品应用

  • BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. ATM/ATR
  1. Medical Research Areas
  2. Epigenetics
  3. Histone Methyltransferase
  1. Medical Research Areas
  2. PI3K/AKT/mTOR
  3. ATM/ATR

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