(S)-5-(((5-Chloro-2-Methylpyridin-3-Yl)Amino)Methyl)-N-(3-Cyclopentyl-1-(Cyclopropylamino)-1-Oxopropan-2-Yl)Thiophene-2-Carboxamide (S)-5-(((5-氯-2-甲基吡啶-3-基)氨基)甲基)-N-(3-环戊基-1-(环丙基氨基)-1-氧代丙烷-2-基)噻吩-2-甲酰胺

CAS 1404456-53-6 MFCD504456536

化学结构图

1404456-53-6
SMILES:

别名和识别编码

PubChem Substance ID70983932
InChIInChI=1S/C23H29ClN4O2S/c1-14-19(11-16(24)12-25-14)26-13-18-8-9-21(31-18)23(30)28-20(10-15-4-2-3-5-15)22(29)27-17-6-7-17/h8-9,11-12,15,17,20,26H,2-7,10,13H2,1H3,(H,27,29)(H,28,30)/t20-/m0/s1
Chemical Name Translation(S)-5-(((5-氯-2-甲基吡啶-3-基)氨基)甲基)-N-(3-环戊基-1-(环丙基氨基)-1-氧代丙烷-2-基)噻吩-2-甲酰胺
Chemical Name(S)-5-(((5-Chloro-2-Methylpyridin-3-Yl)Amino)Methyl)-N-(3-Cyclopentyl-1-(Cyclopropylamino)-1-Oxopropan-2-Yl)Thiophene-2-Carboxamide
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相关文献及参考

  • [2]. Esfandiari A, et al. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016 Mar;15(3):379-91.
  • [1]. Gilmartin AG, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10(3):181-7.
  • [1]. Gilmartin AG, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10(3):181-7.
  • [2]. Esfandiari A, et al. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016 Mar;15(3):379-91.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Phosphatase  (磷酸酶)

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