N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺

CAS 1418033-25-6 MFCD518033256

化学结构图

1418033-25-6
SMILES: Cc1cc(C)cc(C(=O)NOCCCCCC(=O)NO)c1

化学属性

Mol. Weight294.35
Appearance White to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name TranslationN-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺
Chemical NameN-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide
FormulaC15H22N2O4
Synonym LMK235; LMK 235; LMK-235.
IUPAC NameN-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide
InChIKeyVRYZCEONIWEUAV-UHFFFAOYSA-N
InChIInChI=1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
Canonical SMILESO=C(NOCCCCCC(NO)=O)C1=CC(C)=CC(C)=C1
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产品应用

  • LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. LMK-235 demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 = 0.49 and 0.32 μ M respectively).

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Neuronal Signaling
  3. HDAC

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