GDC-0917 (CUDC-427)

CAS 1446182-94-0 MFCD546182940

化学结构图

1446182-94-0
SMILES:

化学属性

Mol. Weight564.7

别名和识别编码

Chemical NameGDC-0917 (CUDC-427)
FormulaC29H36N6O4S
Synonym GDC0917; GDC-0917; GDC 0917; CUDC427; CUDC-427; CUDC 427.
IUPAC Name(S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide
InChIKeyHSHPBORBOJIXSQ-HARLFGEKSA-N
InChIInChI=1S/C29H36N6O4S/c1-18(30-2)24(36)32-23(20-12-7-4-8-13-20)29(38)35-16-9-14-21(35)25(37)34-27-22(19-10-5-3-6-11-19)33-28(40-27)26-31-15-17-39-26/h3,5-6,10-11,15,17-18,20-21,23,30H,4,7-9,12-14,16H2,1-2H3,(H,32,36)(H,34,37)/t18-,21-,23-/m0/s1
Canonical SMILESO=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)CCC1)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3
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产品应用

  • CUDC-427, also known as, GDC-0917, is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic CUDC-427 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways.

系列性分类

  1. Medical Research Areas
  2. Apoptosis
  3. Caspase

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