PF-06447475 3-(4-吗啉-7H-吡咯并[2,3-d]嘧啶-5-基)苯甲腈

CAS 1527473-33-1 MFCD627473331

化学结构图

1527473-33-1
SMILES: N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1

化学属性

Mol. Weight305.33
Appearance White to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation3-(4-吗啉-7H-吡咯并[2,3-d]嘧啶-5-基)苯甲腈
Chemical NamePF-06447475
FormulaC17H15N5O
Synonym PF06447475; PF-06447475; PF 06447475; PF6447475; PF-6447475; PF 6447475.
IUPAC Name3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
InChIKeyBHTWDJBVZQBRKP-UHFFFAOYSA-N
InChIInChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
Canonical SMILESN#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
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产品应用

  • PF06447475 is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the treatment of PD.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Autophagy
  3. LRRK2

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