Rimonabant Hydrochloride 盐酸利莫那班
CAS 158681-13-1 MFCD58681131
化学结构图
SMILES: CC1=C(C2C=CC(Cl)=CC=2)N(N=C1C(=O)NN1CCCCC1)C1=CC=C(Cl)C=C1Cl
化学属性
| Mol. Weight | 500.25 |
|---|---|
| Mol. Formula | C22H22Cl4N4O |
别名和识别编码
| CAS Number | 158681-13-1 |
|---|---|
| Chemical Name | Rimonabant Hydrochloride |
| Synonym | 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl- |
| Chemical Name Translation | 盐酸利莫那班 |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.
相关文献及参考
- [2]. Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13.
- [3]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.
- [4]. Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.
- Carai, M.A.M., et al.: Life Sci., 77, 2339 (2005),
- Despres, J.-P., et al.: N. Engl. J. Med., 353, 2121 (2005),
- Dutta, A.K., et al.: Med. Chem. Res., 5, 54 (1994),
- [1]. Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15
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