Salirasib 法尼基硫代水杨酸

CAS 162520-00-5 MFCD62520005

化学结构图

162520-00-5
SMILES: CC(C)=CCC/C(/C)=C/CC/C(/C)=C/CSC1C=CC=CC=1C(O)=O

化学属性

Mol. Weight359
Mol. FormulaC22H30O2S

别名和识别编码

CAS Number162520-00-5
Chemical NameSalirasib
Synonym 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid
Chemical Name Translation法尼基硫代水杨酸
MDL Number
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分类

  • Aromatics
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.

相关文献及参考

  • [2]. Nevo Y, et al. Chapman J. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PLoS One. 2011 Mar 22;6(3):e18049.
  • [3]. Charette N, et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. Mol Cancer. 2010 Sep 22;9:256.
  • Marciano, D., et al.: J. Med. Chem., 38, 1267 (1995),
  • [1]. Makovski V, et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9.
  • [1]. Makovski V, et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9.
  • [2]. Nevo Y, et al. Chapman J. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Ras  (Ras蛋白)

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