(S)-5-(Aminomethyl)-1-(5,7-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Yl)-1,3-Dihydro-2H-Imidazole-2-Thione Hydrochloride (S)-5-(氨甲基)-1-(5,7-二氟-1,2,3,4-四氢萘-2-基)-1,3-二氢-2H-咪唑-2-硫酮盐酸盐

CAS 170151-24-3 MFCD70151243

化学结构图

170151-24-3
SMILES:

化学属性

Mol. FormulaC14H16ClF2N3S

别名和识别编码

Chemical Name(S)-5-(Aminomethyl)-1-(5,7-Difluoro-1,2,3,4-Tetrahydronaphthalen-2-Yl)-1,3-Dihydro-2H-Imidazole-2-Thione Hydrochloride
Chemical Name Translation(S)-5-(氨甲基)-1-(5,7-二氟-1,2,3,4-四氢萘-2-基)-1,3-二氢-2H-咪唑-2-硫酮盐酸盐
Chemicalbook IDCB22611129
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相关文献及参考

  • [2]. Stanley WC, et al. Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70.
  • [3]. Stanley WC, et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9.
  • [4]. Sabbah HN, et al. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.
  • [1]. Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.J Med Chem. 2006 Feb 9;49(3):1191-7.
  • [1]. Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.J Med Chem. 2006 Feb 9;49(3):1191-7.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Dopamine β-hydroxylase  (多巴胺β-羟化酶 )

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