4-((5,5-Dimethyl-8-(P-Tolyl)-5,6-Dihydronaphthalen-2-Yl)Ethynyl)Benzoic Acid 4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]炔基]苯甲酸

CAS 171746-21-7 MFCD71746217

化学结构图

171746-21-7
SMILES: Cc1ccc(C2=CCC(C)(C)c3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1

化学属性

Mol. Weight392.49
Mol. FormulaC28H24O2

别名和识别编码

CAS Number171746-21-7
Chemical Name4-((5,5-Dimethyl-8-(P-Tolyl)-5,6-Dihydronaphthalen-2-Yl)Ethynyl)Benzoic Acid
Synonym 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid CD 3106
Chemical Name Translation4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]炔基]苯甲酸
LabNetwork Molecule IDLN04612288
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A retinoic acid receptor (RAR) antagonist used for treating chemotherapy and radiation therapy side effects.

相关文献及参考

  • [2]. Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.
  • [3]. Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75.
  • Johnson, A., et al.: J. Med. Chem., 38, 4764
  • [1]. Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.
  • [1]. Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.
  • [2]. Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.
  • [3]. Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. RAR/RXR  (维甲酸受体)

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