Tonabersat

CAS 175013-84-0 MFCD75013840

化学结构图

175013-84-0
SMILES: CC(=O)C1=CC2[C@H](NC(=O)C3C=C(Cl)C(F)=CC=3)[C@H](O)C(C)(C)OC=2C=C1

化学属性

Mol. Weight391.82
Mol. FormulaC20H19ClFNO4

别名和识别编码

CAS Number175013-84-0
Chemical NameTonabersat
Synonym N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-
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分类

  • Aromatics
  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • It is a cholinesterase inhibitor for treating and preventing migraine. An antimigraine agent

相关文献及参考

  • [2]. Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533(7604):493-8.
  • [3]. Kim Y, et al. Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels. Neurotherapeutics. 2017 May 30.
  • Saito, R., et al.: Brain Res., 699, 109
  • [1]. Silberstein SD, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.
  • [1]. Silberstein SD, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27.
  • [2]. Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533(7604):493-8.
  • [3]. Kim Y, et al. Tonabersat Prevents Inflammatory Damage i

系列性分类

  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Gap Junction Protein  (间隙连接蛋白)

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