Trans-4-Methylene-2-Octyl-5-Oxotetrahydrofuran-3-Carboxylic Acid 反式-4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸

CAS 191282-48-1 MFCD91282481

化学结构图

191282-48-1
SMILES: C=C1C(=O)OC(CCCCCCCC)C1C(=O)O

化学属性

Mol. Weight254.3221
Mol. FormulaC14H22O4

别名和识别编码

CAS Number191282-48-1
Chemical NameTrans-4-Methylene-2-Octyl-5-Oxotetrahydrofuran-3-Carboxylic Acid
Synonym (2R,3S)-rel-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid C 75 C75 cpd trans-4-carboxy-5-octyl-3-methylenebutyrolactone trans-C 75
Chemical Name Translation反式-4-亚甲基-2-辛基-5-氧代四氢呋喃-3-羧酸
LabNetwork Molecule IDLN00194653
PubChem Substance ID9881506
InChIInChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
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分类

  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

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相关文献及参考

  • [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.
  • [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.
  • [4]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.
  • Rae, C. et al.: DIab. Obes. Metab., 10, 1271 (2008); Gao, Y. et al.: Cancer Biol. Ther., 5, 978 (2006); Flavin, R. et al.: Fut. Oncol., 6, 551 (2010);
  • [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
  • [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
  • [2]. Makowski K, et al. Differen

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Fatty Acid Synthase (FASN)  (脂肪酸合成酶)

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