Laniquidar

CAS 197509-46-9 MFCD97509469

化学结构图

197509-46-9
SMILES: COC(=O)c1cnc2n1CCc1ccccc1C2=C1CCN(CCc2ccc(OCc3ccc4ccccc4n3)cc2)CC1

化学属性

Mol. Weight584.70674
Appearance yellow solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameLaniquidar
FormulaC37H36N4O3
Synonym Laniquidar; R101933; R 101933; R-101933.
IUPAC Namemethyl 11-(1-(4-(quinolin-2-ylmethoxy)phenethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carboxylate
InChIKeyTULGGJGJQXESOO-UHFFFAOYSA-N
InChIInChI=1S/C37H36N4O3/c1-43-37(42)34-24-38-36-35(32-8-4-2-6-27(32)19-23-41(34)36)29-17-21-40(22-18-29)20-16-26-10-14-31(15-11-26)44-25-30-13-12-28-7-3-5-9-33(28)39-30/h2-15,24H,16-23,25H2,1H3
Canonical SMILESO=C(C1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(CCC5=CC=C(OCC6=NC7=CC=CC=C7C=C6)C=C5)CC\4)OC
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产品应用

  • Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. A study of docetaxel in combination with the new orally administered P-glycoprotein (P-gp) inhibitor R101933 showed that this combination was feasible. However, due to the low oral bioavailability of R101933 and high interpatient variability, no further attempts to increase the level of P-gp inhibition were made.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Transmembrane Transporters
  3. P-gp
  1. Medical Research Areas
  2. Neuronal Signaling
  3. P-gp

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