Vatalanib Dihydrochloride 瓦他拉尼二盐酸盐
CAS 212141-51-0 MFCD12141510
化学结构图
SMILES: ClC1C=CC(=CC=1)NC1=NN=C(CC2C=CN=CC=2)C2C=CC=CC=21
化学属性
| Mol. Weight | 420 |
|---|---|
| Mol. Formula | C20 |
| Melting Point | 284-286 |
| Appearance | White to off-white crystalline solid |
| Solubility | soluble in DMSO, not soluble in water. |
别名和识别编码
| CAS Number | 212141-51-0 |
|---|---|
| Chemical Name | Vatalanib Dihydrochloride |
| Synonym | CGP-79787 N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride PTK787; PTK 787; PTK-787; ZK 222584; ZK222584; ZK-222584; CGP 79787; CGP-797870; ZK-232934; CGP79787D; PTK787/ZK 222584; CGP-7978. |
| Chemical Name Translation | 瓦他拉尼二盐酸盐 |
| Formula | C20H17Cl3N4 |
| IUPAC Name | N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride. |
| InChIKey | AZUQEHCMDUSRLH-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H |
| MDL Number |
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分类
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Tyrosine Kinase Inhibitors
产品应用
- Vatalanib, also known as PTK787, is an orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.
相关文献及参考
- Wood, J.M., et al.: Cancer Res., 60, 2178 (2000),
- Morgan, B., et al.: J. Clin. Oncol., 21, 3955 (2003),
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