BX471 (2R)-1-[[[4-氯-2-(脲基)苯氧基]甲基]羰基]-2-甲基-4-(4-氟苄基)哌嗪

CAS 217645-70-0 MFCD17645700

化学结构图

217645-70-0
SMILES: C[C@@H]1CN(CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O)Cc1ccc(F)cc1

化学属性

Mol. Weight434.89
Mol. FormulaC21H24ClFN4O3

别名和识别编码

Synonym N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea ZK-811752 ZK-811752
CAS Number217645-70-0 (free acid)
InChIKeyXQYASZNUFDVMFH-CQSZACIVSA-N
Chemical NameBX471
Chemical Name Translation(2R)-1-[[[4-氯-2-(脲基)苯氧基]甲基]羰基]-2-甲基-4-(4-氟苄基)哌嗪
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分类

  • {SA} Approved Therapeutics/Drug Candidates, B, Bayer, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones
  • {SNA} Approved Therapeutics/Drug Candidates, B, Bayer,

相关文献及参考

  • [2]. Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.
  • [3]. Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.
  • [4]. Horuk R, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem. 2001 Feb 9;276(6):4199-204.
  • Furuichi K, Gao JL, Horuk R, Wada T, Kaneko S, Murphy PM., Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J. Immunol. 12 , 8670-6, (2008)
  • Horuk R, Clayberger C, Krensky AM, Wang Z, Grone HJ, Weber C, et al., A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J. Biol. Chem. 6 , 4199-204, (2001)
  • Liang M, Mallari C, Rosser M

安全信息

GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
Signal word Warning
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes Xn,N
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Cytokines and Growth Factors - Cytokines, Growth Factors and Hormones
  6. Chemokines - Cytokines and Growth Factors
  7. Chemokine Inhibitors - Chemokines
  1. Medical Research Areas
  2. GPCR & G Protein
  3. CCR  (趋化因子受体)

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