Ozarelix

CAS 295350-45-7 MFCD95350457

化学结构图

295350-45-7
SMILES: CCCCC(N)C(=O)N(C(=O)[C@@H](CCCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O

化学属性

Mol. Weight1459.09
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameOzarelix
FormulaC72H96ClN17O14
Synonym Sequence: AcD2NalD4CpaD3PalSerNMeTyrDHciNleArgProDAlaNH2
IUPAC Name(2S)-N-((R)-1-amino-1-oxopropan-2-yl)-1-((2S,5R,8S,11S,14R,17R,20R)-3-(2-aminohexanoyl)-17-(4-chlorobenzyl)-2-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-(hydroxymethyl)-9-methyl-20-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-14-(pyridin-3-ylmethyl)-5-(4-ureidobutyl)-3,6,9,12,15,18,21-heptaazatricosan-1-oyl)pyrrolidine-2-carboxamide
InChIKeyAFPLCEKVZYMXHQ-CZGJKCRTSA-N
InChIInChI=1S/C72H96ClN17O14/c1-5-6-17-52(74)67(100)90(59(19-12-33-80-71(76)77)70(103)89-34-13-20-58(89)65(98)82-42(2)61(75)94)69(102)53(18-9-10-32-81-72(78)104)84-66(99)60(39-45-24-29-51(93)30-25-45)88(4)68(101)57(41-91)87-64(97)56(38-47-14-11-31-79-40-47)86-63(96)55(36-44-22-27-50(73)28-23-44)85-62(95)54(83-43(3)92)37-46-21-26-48-15-7-8-16-49(48)35-46/h7-8,11,14-16,21-31,35,40,42,52-60,91,93H,5-6,9-10,12-13,17-20,32-34,36-39,41,74H2,1-4H3,(H2,75,94)(H,82,98)(H,83,92)(H,84,99)(H,85,95)(H,86,96)(H,87,97)(H4,76,77,80)(H3,78,81,104)/t42-,52?,53-,54-,55-,56-,57+,58+,59+,60+/m1/s1
Canonical SMILESO=C([C@H]1N(C([C@H](CCCNC(N)=N)N(C(C(N)CCCC)=O)C([C@@H](CCCCNC(N)=O)NC([C@H](CC2=CC=C(O)C=C2)N(C)C([C@H](CO)NC([C@@H](CC3=CC=CN=C3)NC([C@@H](CC4=CC=C(Cl)C=C4)NC([C@@H](CC5=CC=C6C=CC=CC6=C5)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)N[C@H](C)C(N)=O
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产品应用

  • Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer, BPH, infertility, uterine myoma and endometriosis. BPH is a non-cancerous enlargement of the prostate that is caused by testosterone. Unlike LHRH agonists, ozarelix has the potential to reduce testosterone just enough to reduce both prostate size and symptoms without the severe side effects associated with a reduction in testosterone.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor
  1. Medical Research Areas
  2. Neuronal Signaling
  3. Adrenergic Receptor

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