UK-383367

CAS 348622-88-8 MFCD48622888

化学结构图

348622-88-8
SMILES:

化学属性

Mol. Weight324.38
Mol. FormulaC15H24N4O4

别名和识别编码

CAS Number348622-88-8
Chemical NameUK-383367
Synonym (?R)-3-(Aminocarbonyl)-?-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide UK 383367 PF-0417142
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分类

  • Heterocycles
  • Inhibitors
  • Pfizer Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Potent and selective nonpeptidic inhibitor of procollagen C-proteinase (PCP) inhibitor. A potential dermal anti-scarring agent.

相关文献及参考

  • [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.
  • Fish, P.V. et al.: J. Med. Chem., 50, 3442 (2007); Allan, G.A. et al.: Xenobiotica, 36, 399 (2006); Bailey, S. et al.: Biorog. Med. Chem. Lett., 18, 6562 (2008);
  • [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.
  • [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.
  • [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteina

系列性分类


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