Syntelin

CAS 438481-33-5 MFCD38481335

化学结构图

438481-33-5
SMILES: Nc1nc(SCc2nnc(SCC(=O)O)n2-c2ccccc2)nc2sc3c(c12)CCCC3

化学属性

Mol. Weight484.62
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameSyntelin
FormulaC21H20N6O2S3
Synonym Syntelin.
IUPAC Name2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid
InChIKeyInChI=1S/C21H20N6O2S3/c22-18-17-13-8-4-5-9-14(13)32-19(17)24-20(23-18)30-10-15-25-26-21(31-11-16(28)29)27(15)12-6-2-1-3-7-12/h1-3,6-7H,4-5,8-11H2,(H,28,29)(H2,22,23,24)
InChISPRISILOMIVCIR-UHFFFAOYSA-N
Canonical SMILESO=C(O)CSC1=NN=C(CSC2=NC(N)=C(C3=C(CCCC3)S4)C4=N2)N1C5=CC=CC=C5
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产品应用

  • Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. ATPase

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