4-(4-(3-(Pyridin-2-Yl)-1H-Pyrazol-4-Yl)Pyridin-2-Yl)-N-(Tetrahydro-2H-Pyran-4-Yl)Benzamide 4-[4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基]-N-(四氢吡喃-4-基)苯甲酰胺
CAS 452342-67-5 MFCD52342675
化学结构图
SMILES: O=C(NC1CCOCC1)c1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1
化学属性
| Mol. Weight | 425.48242 |
|---|---|
| Appearance | solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 4-[4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基]-N-(四氢吡喃-4-基)苯甲酰胺 |
|---|---|
| Chemical Name | 4-(4-(3-(Pyridin-2-Yl)-1H-Pyrazol-4-Yl)Pyridin-2-Yl)-N-(Tetrahydro-2H-Pyran-4-Yl)Benzamide |
| Formula | C25H23N5O2 |
| Synonym | GW788388; GW-788388; GW 788388 |
| IUPAC Name | 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide |
| InChIKey | SAGZIBJAQGBRQA-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31) |
| Canonical SMILES | O=C(NC1CCOCC1)C2=CC=C(C3=NC=CC(C4=CNN=C4C5=NC=CC=C5)=C3)C=C2 |
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产品应用
- GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542. We studied its effect in vitro and found that it inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Further, it blocked TGF-beta-induced Smad activation and target gene expression, while decreasing epithelial-mesenchymal transitions and fibrogenesis.
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