5-[3-(Phenylmethoxy)Phenyl]-7-[Trans-3-(1-Pyrrolidinylmethyl)Cyclobutyl]-7H-Pyrrolo[2,3-d]Pyrimidin-4-Amine 5-(3-苄氧基苯基)-7-[反式-3-[(吡咯烷-1-基)甲基]环丁基]-7H-吡咯并[2,3-D]嘧啶-4-胺
CAS 475488-23-4 MFCD75488234
化学结构图
SMILES: Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@H](CN2CCCC2)C1
化学属性
| Mol. Weight | 453.57864 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 5-(3-苄氧基苯基)-7-[反式-3-[(吡咯烷-1-基)甲基]环丁基]-7H-吡咯并[2,3-D]嘧啶-4-胺 |
|---|---|
| LabNetwork Molecule ID | LN01342171 |
| Chemical Name | 5-[3-(Phenylmethoxy)Phenyl]-7-[Trans-3-(1-Pyrrolidinylmethyl)Cyclobutyl]-7H-Pyrrolo[2,3-d]Pyrimidin-4-Amine |
| PubChem Substance ID | 9825149 |
| InChI | InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)/t21-,23- |
| Synonym | NVP ADW742 NVP-ADW742 NVP-ADW742; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A. |
| Formula | C28H31N5O |
| IUPAC Name | 5-(3-(benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| InChIKey | LSFLAQVDISHMNB-AFARHQOCSA-N |
| Canonical SMILES | NC1=C2C(N([C@H]3C[C@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1 |
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产品应用
- NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.
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