ADPM06
CAS 490035-90-0 MFCD90035900
化学结构图
SMILES: COc1ccc(C2=[N+]3C(=Nc4c(-c5ccccc5)c(Br)c(-c5ccc(OC)cc5)n4[B-]3(F)F)C(c3ccccc3)=C2Br)cc1
化学属性
| Mol. Weight | 715.19 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | ADPM06 |
|---|---|
| Formula | C34H24BBr2F2N3O2 |
| Synonym | Azadipyrromethane ADPM06; ADPM 06; ADPM-06. |
| IUPAC Name | 2,8-dibromo-5,5-difluoro-3,7-bis(4-methoxyphenyl)-1,9-diphenyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinin-4-ium-5-uide. |
| InChIKey | YVKIKMDAXWFEJI-UHFFFAOYSA-N |
| InChI | InChI=1S/C34H24BBr2F2N3O2/c1-43-25-17-13-23(14-18-25)31-29(36)27(21-9-5-3-6-10-21)33-40-34-28(22-11-7-4-8-12-22)30(37)32(42(34)35(38,39)41(31)33)24-15-19-26(44-2)20-16-24/h3-20H,1-2H3 |
| Canonical SMILES | COC1=CC=C(C2=C(Br)C(C3=CC=CC=C3)=C(N2[B-]4(F)F)N=C5[N+]4=C(C6=CC=C(OC)C=C6)C(Br)=C5C7=CC=CC=C7)C=C1 |
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产品应用
- ADPM06 is an emerging non-porphyrin PDT agent which has been specifically designed for therapeutic application. It was demonstrated that ADPM06-PDT was well tolerated in vivo and elicited impressive complete response rates in various models of cancer when a short drug-light interval was applied. Using a drug and light combination that reduced the clonogenicity of MDA-MB-231 cells by >90%. PDT-induced apoptosis was also found to be independent of p53 tumor suppressor status. A robust therapeutic response in vivo was demonstrated, with a substantial reduction in tumor proliferation observed, as well as a rapid induction of apoptosis and initiation of ER stress, mirroring numerous aspects of the mechanism of action of ADPM06 in vitro. Finally, using a combination of (18) F-labeled 3'-deoxy-3'-fluorothymidine ((18) F-FLT) nuclear and optical imaging, a considerable decrease in tumor proliferation over 24-hr in two models of human cancer was observed. Taken together, this data clearly estab
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