2-氨基-5 - 苯甲酰基苯并咪唑 2-氨基-5 - 苯甲酰基苯并咪唑
CAS 52329-60-9 MFCD52329609
化学结构图
SMILES: NC1NC2C=CC(=CC=2N=1)C(=O)C1C=CC=CC=1
化学属性
| Mol. Weight | 237 |
|---|---|
| Mol. Formula | C14H11N3O |
别名和识别编码
| CAS Number | 52329-60-9 |
|---|---|
| Chemical Name | Ketone, 2-amino-6-benzimidazolyl phenyl |
| Synonym | Methanone, (2-amino-1H-benzimidazol-5-yl)phenyl- (2-Amino-1H-benzimidazol- (2-Amino-1H-benzimidazol-6-yl)phenylmethanone R 18986 Benzimidazole, 2-amino-5-benzoyl- Ketone, 2-amino-5-benzimidazolyl phenyl G-1029 |
| Chemical Name Translation | 2-氨基-5 - 苯甲酰基苯并咪唑 |
| Wiswesser Line Notation | T56 BM DNJ CZ GVR |
| MDL Number |
信息真实价格透明
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分类
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- The minor urinary metabolite of Mebendazole (M200500) in man. Mebendazole impurity.
相关文献及参考
- [2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.
- Leban, J., et al.: Bioorg. Med. Chem. Lett., 17, 5858
- [1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158.
- [1]. Majewsky M, et al. Systematic identification of suspected anthelmintic benzimidazole metabolites using LC-MS/MS. J Pharm Biomed Anal. 2018;151:151-158.
- [2]. Pantziarka P, et al. Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. Ecancermedicalscience. 2014;8:443. Published 2014 Jul 10.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 257 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 755 mg/kg SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
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