5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxamide 5-((4-溴-2-氟苯基)氨基)-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并[d]咪唑-6-甲酰胺

CAS 606143-89-9 MFCD06143899

化学结构图

606143-89-9
SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(C(=O)NOCCO)cc21

化学属性

Mol. Weight441.22681
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation5-((4-溴-2-氟苯基)氨基)-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并[d]咪唑-6-甲酰胺
LabNetwork Molecule IDLN01299028
Chemical Name5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxamide
PubChem Substance ID10288191
InChIInChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
Synonym MEK162 MEK162; MEK-162; MEK 162; ARRY162; ARRY-162; ARRY 162; ARRY438162, Binimetinib; Brand name: Mektovi. binimetinib
FormulaC17H15BrF2N4O3
IUPAC Name5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide.
InChIKeyACWZRVQXLIRSDF-UHFFFAOYSA-N
Canonical SMILESO=C(C1=C(NC2=CC=C(Br)C=C2F)C(F)=C3N=CN(C)C3=C1)NOCCO
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • Binimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor. In preclinical studies, MEK162 showed significant antitumor activities in cell lines and animal models. MEK162 is the first targeted therapy to show activity in patients with NRAS -mutated melanoma and might offer a new option for a cancer with few effective treatments.

安全信息

Hazard statements
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. MEK

相关产品推荐