Tozasertib 陶扎色替

CAS 639089-54-6 MFCD39089546

化学结构图

639089-54-6
SMILES: Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)[nH]n1

化学属性

Mol. Weight464.59
Mol. FormulaC23H28N8OS
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

CAS Number639089-54-6
Chemical NameTozasertib
Synonym MK 0457 N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide VX 680 VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib
Chemical Name Translation陶扎色替
FormulaC23H28N8OS
IUPAC Name(N-[4({4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5 -yl)amino]pyrimidin-2-yl}thio)phenyl]cyclopropanecarboxamide)
InChIKeyGCIKSSRWRFVXBI-UHFFFAOYSA-N
InChIInChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
Canonical SMILESO=C(C1CC1)NC2=CC=C(SC3=NC(NC4=CC(C)=NN4)=CC(N5CCN(C)CC5)=N3)C=C2
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分类

  • Aromatics
  • Heterocycles
  • Mutagenesis Research Chemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Tozasertib, also known as VX-680, MK0457 or VE465, is a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.

相关文献及参考

  • Ulisse, S., et al.: J. Endocrinol., 204, 135 (2010),
  • McDermott, U., et al.: Cancer Res., 70, 1625 (2010),
  • Donato, N., et al.: Biochem., Pharmacol., 79, 688 (2010),

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Cell Cycle
  3. Aurora Kinase

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