L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.

CAS 684276-17-3 MFCD84276173

化学结构图

684276-17-3
SMILES: O=c1[nH]c(SCCN2CCCCC2)nc2ccccc12

化学属性

Mol. Weight289.39586
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameL-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.
FormulaC15H19N3OS
Synonym L2286; L 2286; L-2286.
IUPAC Name2-((2-(piperidin-1-yl)ethyl)thio)quinazolin-4(3H)-one
InChIKeyQEAAIHDHSHTGMZ-UHFFFAOYSA-N
InChIInChI=1S/C15H19N3OS/c19-14-12-6-2-3-7-13(12)16-15(17-14)20-11-10-18-8-4-1-5-9-18/h2-3,6-7H,1,4-5,8-11H2,(H,16,17,19)
Canonical SMILESO=C1NC(SCCN2CCCCC2)=NC3=C1C=CC=C3
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产品应用

  • L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. DNA Damage
  3. PARP

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