4-Methyl-N1-(3-Phenylpropyl)Benzene-1,2-Diamine 4-甲基-N1-(3-苯基丙基)-1,2-苯二胺
CAS 749886-87-1 MFCD49886871
化学结构图
SMILES: Cc1ccc(NCCCc2ccccc2)c(N)c1
化学属性
| Mol. Weight | 240.3434 |
|---|---|
| Mol. Formula | C16H20N2 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 749886-87-1 |
|---|---|
| Chemical Name | 4-Methyl-N1-(3-Phenylpropyl)Benzene-1,2-Diamine |
| Synonym | JSH-23 JSH23; JSH 23; JSH-23. |
| Chemical Name Translation | 4-甲基-N1-(3-苯基丙基)-1,2-苯二胺 |
| Formula | C16H20N2 |
| IUPAC Name | 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine |
| InChIKey | YMFNPBSZFWXMAD-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3 |
| Canonical SMILES | NC1=CC(C)=CC=C1NCCCC2=CC=CC=C2 |
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分类
- Amines
- Aromatics
- Inhibitors,
产品应用
- JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. JSH-23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear translocation of p65/p50 subunit was inhibited by JSH-23 treatment in the sciatic nerve. The treatment also lowered the elevated IL-6, TNF-α, cyclo-oxygenase (COX-2) and inducible nitric oxide synthase (iNOS) levels/expression, indicating reduction in the inflammatory damage of the sciatic nerve. Apart from these effects, JSH-23 also increased Nrf2 and hemeoxygenase-1 (HO-1) levels which could imply its potential in increasing the strength of antioxidant defence.
相关文献及参考
- Shin, H.M., et al.: FEBS Lett., 571, 50 (2004),
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