1-(2-Methoxyethyl)-2-Methyl-4,9-Dioxo-3-(Pyrazin-2-Ylmethyl)-4,9-Dihydro-1H-Naphtho[2,3-d]Imidazol-3-Ium Bromide 1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(吡嗪-2-基甲基)-4,9-二氢-1H-萘并[2,3-d]咪唑-3-鎓溴化物
CAS 781661-94-7 MFCD81661947
化学结构图
SMILES: COCC[n+]1c2c(n(Cc3cnccn3)c1C)C(=O)c1ccccc1C2=O.[Br-]
化学属性
| Mol. Weight | 1 |
|---|---|
| Appearance | White Solid powder |
| Solubility | Soluble in DMSO, not in water |
| Mol. Formula | H2 |
别名和识别编码
| Synonym | Sepantronium Bromide, YM-155 YM155; YM 155; YM-155; Sepantronium bromide |
|---|---|
| Chemical Name Translation | 1-(2-甲氧基乙基)-2-甲基-4,9-二氧代-3-(吡嗪-2-基甲基)-4,9-二氢-1H-萘并[2,3-d]咪唑-3-鎓溴化物 |
| Chemical Name | 1-(2-Methoxyethyl)-2-Methyl-4,9-Dioxo-3-(Pyrazin-2-Ylmethyl)-4,9-Dihydro-1H-Naphtho[2,3-d]Imidazol-3-Ium Bromide |
| Formula | C20H19BrN4O3 |
| IUPAC Name | 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide. |
| InChIKey | QBIYUDDJPRGKNJ-UHFFFAOYSA-M |
| InChI | InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1 |
| Canonical SMILES | O=C(C1=C2[N+](CCOC)=C(C)N1CC3=NC=CN=C3)C4=C(C=CC=C4)C2=O.[Br-] |
| MDL Number | |
| CAS Number | 781661-94-7 |
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产品应用
- Sepantronium bromide, also known as YM-155, is a small-molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and tumor cell apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is expressed during embryonal development and is absent in most normal, terminally differentiated tissues; upregulated in a variety of human cancers, its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy.
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