Methyl 4-(2-Fluoro-3-(3-(6-Methylpyridin-3-Yl)Ureido)Benzyl)Piperazine-1-Carboxylate 4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯

CAS 873697-71-3 MFCD73697713

化学结构图

873697-71-3
SMILES: COC(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2F)CC1

化学属性

Mol. Weight401.43
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯
Chemical NameMethyl 4-(2-Fluoro-3-(3-(6-Methylpyridin-3-Yl)Ureido)Benzyl)Piperazine-1-Carboxylate
FormulaC20H24FN5O3
Synonym Omecamtiv mecarbil; CK1827452; CK 1827452; CK1827452.
IUPAC Namemethyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate
InChIKeyRFUBTTPMWSKEIW-UHFFFAOYSA-N
InChIInChI=1S/C20H24FN5O3/c1-14-6-7-16(12-22-14)23-19(27)24-17-5-3-4-15(18(17)21)13-25-8-10-26(11-9-25)20(28)29-2/h3-7,12H,8-11,13H2,1-2H3,(H2,23,24,27)
Canonical SMILESO=C(N1CCN(CC2=CC=CC(NC(NC3=CC=C(C)N=C3)=O)=C2F)CC1)OC
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产品应用

  • Omecamtiv mecarbil, also known as CK-1827452, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. Omecamtiv Mecarbil specifically targets and activates myocardial ATPase and improves energy utilization. Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency. (source: http://en.wikipedia.org/wiki/Omecamtiv_mecarbil)

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. MARK
  3. ATPase

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