Anacetrapib 胆固醇脂转移蛋白阻滞剂
CAS 875446-37-0 MFCD75446370
化学结构图
SMILES: COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C
化学属性
| Mol. Weight | 637.51 |
|---|---|
| Mol. Formula | C30H25F10NO3 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 875446-37-0 |
|---|---|
| Chemical Name | Anacetrapib |
| Synonym | ######## MK0859; MK-0859; MK 0859; Anacetrapib |
| Chemical Name Translation | 胆固醇脂转移蛋白阻滞剂 |
| Formula | C30H25F10NO3 |
| IUPAC Name | (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one. |
| InChIKey | MZZLGJHLQGUVPN-HAWMADMCSA-N |
| InChI | InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1 |
| Canonical SMILES | O=C1O[C@H](C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)[C@H](C)N1CC3=CC(C(F)(F)F)=CC=C3C4=CC(C(C)C)=C(F)C=C4OC |
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分类
- Aromatics
- Chiral Reagents
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Anacetrapib, also known as MK-0859, is a CETP inhibitor being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.
相关文献及参考
- Krishna, R. et al.: Br. J. Clin. Pharmacol., 67, 520 (2009); Vergeer, M. et al.: Nat. Clin. Pract. Cardiovasc. Med., 5, 302 (2008); Masson, D.: Curr. Opin. Invest. Drugs, 10, 980 (2009);
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