STF-118804 4-(5-甲基-4-(对甲苯磺酰甲基)恶唑-2-基)-N-(吡啶-3-基甲基)苯甲酰胺

CAS 894187-61-2 MFCD94187612

化学结构图

894187-61-2
SMILES: Cc1ccc(S(=O)(=O)Cc2nc(-c3ccc(C(=O)NCc4cccnc4)cc3)oc2C)cc1

化学属性

Mol. Weight461.53
Appearance White to off-white Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation4-(5-甲基-4-(对甲苯磺酰甲基)恶唑-2-基)-N-(吡啶-3-基甲基)苯甲酰胺
PubChem Substance ID20916937
InChIInChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29)
Synonym STF-118804 STF118804; STF 118804; STF118804.
Chemical NameSTF-118804
FormulaC25H23N3O4S
IUPAC Name4-(5-methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
InChIKeyDLFCEZOMHBPDGI-UHFFFAOYSA-N
Canonical SMILESO=C(NCC1=CC=CN=C1)C2=CC=C(C3=NC(CS(=O)(C4=CC=C(C)C=C4)=O)=C(C)O3)C=C2
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产品应用

  • STF-118804 is a potent and highly specific NAMPT inhibitor ( nicotinamide phosphoribosyl transferase inhibitor), which improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia, and targets leukemia stem cells.

相关文献及参考

  • [1]. Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Transferase
  1. Medical Research Areas
  2. Metabolism
  3. NAMPT  (烟酰胺磷酸核糖转移酶)

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