(3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid monosodium salt (3R,5S,6E)-rel-7- [3-(4-氟苯基)-1-异丙基-1H-吲哚-2-基]-3,5-二羟基-6-庚烯酸单钠盐
CAS 93957-55-2 MFCD93957552
化学结构图
SMILES: [Na+].[2H]C([2H])([2H])C(N1C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C2C=CC=CC1=2)C1C=CC(F)=CC=1)C([2H])([2H])[2H] |&1:10,13|
化学属性
| Mol. Weight | 439 |
|---|---|
| Mol. Formula | C24H19D6FNNaO4 |
别名和识别编码
| CAS Number | 93957-55-2 |
|---|---|
| Chemical Name | (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid monosodium salt |
| Synonym | Lipaxan Fluindostatin (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic Acid Sodium Salt Fluvastatin sodium XU 62-320 Primexin Lescol |
| Chemical Name Translation | (3R,5S,6E)-rel-7- [3-(4-氟苯基)-1-异丙基-1H-吲哚-2-基]-3,5-二羟基-6-庚烯酸单钠盐 |
| MDL Number | MFCD00929076 |
| PubChem Substance ID | 160870917 |
| Merck Number | 4218 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A synthetic HMG-CoA reductase inhibitor. Antilipemic.
相关文献及参考
- [2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.
- [3]. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.
- [4]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.
- Dain, J.G., et al.: Drug Metab. Disposit., 21, 567 (1993),
- Tse, F.L.S., et al.: J. Clin. Pharmacol., 32, 630 (1992),
- Yuan, J., et al.: Atherosclerosis, 87, 147 (1991),
- [1]. Araújo FA, Rocha MA, Capetti
- [1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print]
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 396 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,853,1995
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