2,4’-二溴苯乙酮 2,4’-二溴苯乙酮

CAS 99-73-0 MFCD00000200

化学结构图

99-73-0
SMILES: O=C(CBr)c1ccc(Br)cc1

化学属性

Mol. FormulaC8H6Br2O
Mol. Weight278
Melting Point108-110
TSCAT
Density1.848
Stability对热和光敏感
Boiling Point1415°C/760mm
SolubilitySoluble in DMSO (5 mg/ml), methanol (20 mg/ml), toluene, and ethanol. Insoluble in water.
Flash Point>;230 °F
Appearance 白色片状结晶。熔点51℃，沸点255.5℃（97.9kPa），130℃（1.46kPa），117℃（0.93kPa）。溶于乙醇、乙醚、冰醋酸、苯、二硫化碳和石油醚，不溶于水。易随水蒸气挥发。

别名和识别编码

Chemical Name2,4’-二溴苯乙酮
CAS Number99-73-0
Alfabeta NameDIBROMOACETOPHENONE 24-,'
MDL NumberMFCD00000200
Synonym 1-(4 1-(4-溴苯基)乙酮 2,4'-二溴苯乙酮, 98+% 2,4ˊ-二溴乙酰苯 2,4’-dibromo-acetophenon 2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE 2-Bromo-1-( 2-Bromo-1-(4-bromophenyl)ethanone; 4'-Bromophenacyl bromide 2-Bromo-4'-bromoac 4'-Bromophenacyl Bromide 4'-BROMOPHENACYL BROMIDE 4,OMEGA-DIBROMOACET 4-溴代乙酰苯 4-溴苯甲酰甲基溴代铬 4′-Bromophenacyl bromide p-Bromophenacyl bromide Bromomethyl 4-bromophenyl ketone Ethanone, 2-bromo-1-(4-bromophenyl)- P-溴苯乙酮 alpha,4-Dibromoacetophenone {} {} {Chemical α,4-Dibro α,4-dibromo-acetophenone 对溴苯乙酰溴 对溴苯乙酰溴;对溴溴代苯乙酮;对-α-二溴苯乙酮
PubChem Substance ID87566888
EC Number202-783-6
Beilstein Registry Number607604
Reaxys-RN607604
Merck Number1427
Chemical Name Translation2,4’-二溴苯乙酮
Wiswesser Line NotationE1VR DE
LabNetwork Molecule IDLN00116210
InChIInChI=1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C7 to C8, Carbonyl Compounds, Cell Biology, Chemical Synthesis,
  • {SNA} Analytical Reagents, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C7 to C8, Carbonyl Compounds, Cell Biology, Chemical Synthesis, D-DIF, Derivatization Reagents, Derivatization Reagents HPLC, Derivatization agents, Fluorescence, Halogenated, Ketones, Luminescent Compounds/Detection, Organic Building Blocks
  • {SNA} Alkylation Reagents,
  • {SNA} Al

产品应用

  • A cell-permeable, and non-ATP competitive inhibitor of GSK-3β

相关文献及参考

  • Merck 14 ,1427
  • For use in the protection of phenols and carboxylic acids, see: Tetrahedron Lett., 343 (1970).
  • Short: III/20b
  • Merck: 14,1427
  • Short: EINECS
  • 2. Qiu, J., et al. J. Chromatogr. A. 1235 , 132-140, (2012) 摘要
  • The O-methyl oxime has been used to N-alkylate pyridines. The products can be cyclized with triethylamine to give imidazo[1,2-a]pyridines in high yield: Synthesis, 927 (1996).
  • Reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters: Anal. Chem., 47, 1797, (1975).
  • Merck: 14,1427 Beilstein: 7,IV,652

安全信息

Warnings 危化品目录(2015) LACHRYMATOR, CORROSIVE
GHS Symbol
WGK Germany2
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 8 C C,Xi,Xn
RTECSAM6950000
Precautionary statements
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 3261 UN 3261 8/PG 2
Storage condition 0-10 2-8°C 储存温度2-8℃ 0-10°C 避光保存
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupII
Hazard Class8 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEXPAG Medicina Experimentalis.  (Basel, Switzerland)  V.1-11, 1959-64;
   V.18-19, 1968-69.  For publisher information, see JNMDBO.
   Volume(issue)/page/year: 11,137,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02407

Restrict 危险品

其他信息

  • 灭火剂:二氧化碳、砂土、泡沫
  • 毒性分级:中毒
  • 用途二:用作医药中间体
  • 图谱信息:2,4'-二溴苯乙酮(99-73-0)质谱(MS) 2,4'-二溴苯乙酮(99-73-0)红外图谱(IR1) 2,4'-二溴苯乙酮(99-73-0)红外图谱(IR2) 2,4'-二溴苯乙酮(99-73-0)核磁图( 1 HNMR) 2,4'-二溴苯乙酮(99-73-0)红外图谱(IR3) 2,4'-二溴苯乙酮(99-73-0)核磁图( 13 CNMR)
  • Hazard Note:Irritant
  • 上游原料:4-溴苯乙酮
  • Acros Organi
  • 2,4'-二溴苯乙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80021280 4-溴苯乙酰基溴 25g 465元 2011/04/16 D0164 4-溴苯甲酰甲基溴 4-Bromophenacyl Bromide 25G 582元 2011/04/16 A5501 4-溴苯乙酰溴[用于高效液相色谱标记] 4-Bromophenacyl Bromide [for HPLC L
  • 急性毒性:口服-小鼠 LD50: 2000 毫克/公
  • 图谱信息:4-溴苯乙
  • TCI Shanghai:4-溴苯乙酰溴[用于高效液相色谱标记] 4-Bromophenacyl Bromide [for HPLC Labeling],>;99.0%(T)(99-73-0)
  • 用途二:分析试剂。用于HPLC标记。
  • 类别:有毒物品
  • 方法一:由对溴苯乙酮溴化而得。将对溴苯乙酮溶解在冰醋酸中，在20℃以下滴加溴素。
  • Hazard Note:Corrosive/Lachrymatory
  • Sigma Aldrich:99-90-1(sigmaaldrich)
  • 用途三:有机合成中间体。用于染料、医药及试剂。
  • 用途一:分析试剂。该品为有机有毒品。
  • 4-溴苯乙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010357 4-溴苯乙酮 100g 320元 2011/04/16 B0537 4'-溴苯乙酮 4'-Bromoacetophenone 500G 2090元 2011/04/16 B0537 4'-溴苯乙酮 4'-Bromoacetophenone 25G 262元
  • 2,4'-二溴苯乙酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80021280 4-溴苯乙酰基溴 25g 465元 2011/04/16 D0164 4-溴苯甲酰甲基溴 4-Bromophenacyl Bromide 25G 58
  • 可燃性危险特性:明火可燃; 受热分解有毒溴化物气体
  • Alfa Aesar:4'-溴苯乙酮,98% 4'-Bromoacetophenone, 98%(99-90-1)
  • TSCA:T
  • 方法一:由溴苯与乙酐在三氯化铝存在下反应而得。将溴苯和干燥的二硫化碳加入反应器中，投入粉状的无水三氯化铝，加热至开始回流，停止加热，滴加乙酐，加完后再回流1h，蒸出二硫化碳，趁热将反应物倒入盐酸冰水混合液中，滤干，减压蒸馏即得成品。
  • MSDS 信息:p-Bromoacetophenone(99-90-1).msds
  • Alfa Aesar:2,4'-二溴苯乙酮,98+% 2,4'-Dibromoacetophenone, 98+%(99-73-0)
  • 上游原料:溴苯 --> 三氯化铝
  • 下游产品:3-(4-溴苯基)-5-氨基异噁唑
  • 外观性质:灰白色针状结晶。
  • 敏感性:Lach
  • 不溶于水，极溶于热醇，溶于乙醇、乙醚和氯仿。

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Luminescent Compounds/Detection - Biochemicals and Reagents
  4. Derivatization agents - Luminescent Compounds/Detection
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C7 to C8 - Ketones
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents HPLC - Derivatization Reagents
  5. Fluorescence - Derivatization Reagents HPLC
  6. Ketones - Fluorescence
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents HPLC - Derivatization Reagents
  5. HPLC Derivatization Reagents, by Application - Derivatization Reagents HPLC
  6. Carboxylic Acids - HPLC Derivatization Reagents, by Application
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic Ketones
  1. Analytical & Chromatography 分析化学与色谱
  2. Labeling Reagents for HPLC
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones 酮
  6. C3 to C6
  1. Analytical & Chromatography 分析化学与色谱
  2. HPLC
  3. Derivatization Reagents
  4. Fluorescence
  5. Carbonyl Chlorides
  1. Analytical & Chromatography 分析化学与色谱
  2. HPLC
  3. Derivatization Reagents
  4. Fluorescence
  5. Halogenated
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents HPLC
  4. Fluorescence
  5. Carbonyl Chlorides
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents HPLC
  4. Fluorescence
  5. Halogenated
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Chemiluminescent compounds

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