2-Chlorobenzoyl Chloride 2-氯苯甲酰氯(易涉毒)

CAS 609-65-4 MFCD00000660

化学结构图

609-65-4
SMILES: O=C(Cl)c1ccccc1Cl

化学属性

Mol. FormulaC7H4Cl2O
Mol. Weight175
Density1.382
Refractive index1.5710 to 1.5730
Boiling Point238
Melting Point-4 - -3
Flash Point124°C(lit.)
TSCAYes
Stability对湿度敏感
Appearance D 1.5718，相对密度 1.382，溶于有机溶剂，遇水分解。 邻氯苯甲酰氯是黄色液体，m.p.-4～-3℃，b.p.238℃，n 20

别名和识别编码

Chemical Name2-Chlorobenzoyl Chloride
Synonym 2-Chloro benzoyl chloride OCOC 2-氯苯甲酰氯 Benzoyl chloride, o-chloro- 2-Chlorbenzoesäurechlorid 2-氯苯甲酰氯,97% 2-Chlorobenzoylchloride,97% 氯苯甲醯氯 O-CHLOROBENZOYL CHLORIDE o-Chlorobenzoyl chloride Benzoyl chloride, 2-chloro- (9CI) 47) ORTHO CHLORO BENZOYL CHLORIDE 2-chloro-benzoylchlorid 2-Chlor-benzoylchlorid 2-Chlorbenzoylchlorid 邻氯化苯甲酰氯 benzoyl chloride, 2-chloro- OCOC; 2-Chlorobenzoic acid chloride 2-chlorobenzoyl chloride 2-CHLOROBENZOIC ACID CHLORIDE Benzoylchloride,2-chloro- 2-chloro-benzoyl chloride Benzoyl chloride, o-chloro- o-Chlorbenzoylchlorid 2-chlorobenzoic acid chloride 2-Chlorobenzoyl Chloride o-Chlorobenzoyl Chloride chlorobenzoylchloride o-Chlorobenzonyl chloride 2-氯苯甲酰氯(邻氯苯甲酰氯) 氯化邻氯苯甲酰 邻氯苯甲酰氯 LABOTEST-BB LTBB000568 o-Chlorbenzoylchlorid 2-CHLOROBENZOYL CHLORIDE 邻氯化苯甲酰氯,2-氯苯甲酰氯,氯化邻氯苯甲酰
MDL NumberMFCD00000660
CAS Number609-65-4
EC Number210-194-0
Beilstein Registry Number386435
PubChem Substance ID69110
Reaxys-RN386435
Chemical Name Translation2-氯苯甲酰氯(易涉毒)
InChIKeyONIKNECPXCLUHT-UHFFFAOYSA-N
LabNetwork Molecule IDLN00193508
InChIInChI=1S/C7H4Cl2O/c8-6-4-2-1-3-5(6)7(9)10/h1-4H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; carbonyl chloride; 1fragment
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • 医药及染料中间体。用于全身麻醉药氯胺酮盐酸盐；非麻醉性镇咳药敌退咳等的生产。

相关文献及参考

  • Can be used to introduce a carboxyl group into an aromatic ring by Friedel-Crafts acylation, followed by cleavage of the resulting ketone with KO-t-Bu. With this aryl group, cleavage occurs in only one of the two possible senses. For an example, (ferrocenecarboxylic acid), see: Org. Synth. Coll., 6, 625 (1988).
  • Short: III/35E
  • Short: III/20b
  • Short: III/38B
  • Beilstein:9,336

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupII
UN Number 3265
Storage condition Moisture Sensitive
Hazard Codes 8 C
Hazard Class8
Warnings 危化品目录(2015)
Restrict 危险品

其他信息

  • 溶于醇，醚，丙酮，不溶于水。遇水分解。
  • 上游原料:苄基氯 --> 2-氯苯甲酸
  • 用途一:主要用于克霉唑等的中间体及邻氯苯甲酸的制备和三氯杀螨剂的生产
  • MSDS 信息:2-Chlorobenzoic acid chloride(609-65-4).msds
  • 方法二:由邻氯苯甲酸与氯化亚砜反应而得：将邻氯苯甲酸与氯化亚砜搅拌加热溶解，升温回流0.5h。然后蒸去过量的氯化亚砜，再进行常压蒸馏，收集220-230℃馏分而得粗品，最后减压蒸馏而得成品。收率为85%-90%。
  • MOL 文件:609-65-4.mol
  • 用途二:用作有机合成中间体
  • Acros Organics:2-氯苯甲酰氯 2-Chlorobenzoyl chloride, 98%(609-65-4)
  • 方法一:其制法可用 α，α，α，2-四氯甲苯直接水解得到或用邻氯苯甲酸和酰氯化剂 SOCl 2 、PCl 3 等酰氯化可得产品，
  • 邻氯苯甲酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80032826 2-氯苯甲酰氯;氯化邻氯苯甲酰;邻氯苯甲酰氯 100ml 46元 2011/04/16 C0140 2-氯苯甲酰氯 2-Chlorobenzoyl Chloride 500ML 909元 2011/04/16 C0140 2-氯苯甲酰氯 2-Chlorobenzoyl Chloride 25ML 160元
  • TCI Shanghai:2-氯苯甲酰氯 2-Chlorobenzoyl Chloride,>;95.0%(GC)(T)(609-65-4)
  • 下游产品:2-氯苯甲酸 --> 灭幼脲 --> 克霉唑 --> 四螨嗪 --> 氯氨酮相关物质A --> 2'-氯苯基乙酮 --> 邻氯苯基环戊基酮 --> 氯安定 --> 2-氯二苯甲酮 --> 2-氯苯甲酰胺 --> 2-氯-4'-氟二苯甲酮 --> 7-溴-5-(2-氯苯基)-2,3-二氢-2-(甲氧基甲基)-1-甲基-1H-1,4-苯并二氮杂卓 --> 氯苯嘧啶醇
  • 用途四:医药及染料中间体。用于全身麻醉药氯胺酮盐酸盐、非麻醉性镇咳药敌退咳等的生产。
  • 海关编码:29163900
  • 图谱信息:邻氯苯甲酰氯(609-65-4)红外图谱(IR2) 邻氯苯甲酰氯(609-65-4)Raman光谱 邻氯苯甲酰氯(609-65-4)核磁图( 13 CNMR) 邻氯苯甲酰氯(609-65-4)核磁图( 1 HNMR) 邻氯苯甲酰氯(609-65-4)质谱(MS) 邻氯苯甲酰氯(609-65-4)红外图谱(IR1)
  • Sigma Aldrich:609-65-4(sigmaaldrich)
  • 用途五:医药及染料中间体。用于全身麻醉药氯胺酮盐酸盐；非麻醉性镇咳药敌退咳等的生产。
  • Hazard Note:Corrosive/Moisture Sensitive
  • Alfa Aesar:2-氯苯甲酰氯,97% 2-Chlorobenzoyl chloride, 97%(609-65-4)
  • 用途三:邻氯苯甲酰氯是苯甲酰脲类杀虫剂杀铃脲和灭幼脲的中间体，也是杀螨剂四螨嗪和杀菌剂氟苯嘧啶醇的中间体。
  • 存储注意事项:湿度敏感
  • 敏感性:Moisture Sensitive
  • F:19-21

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Reduction - Synthetic Reagents
  4. Alkali Metals - Reduction
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  1. Acyl halide
  2. acyl chloride

相关产品推荐

393-52-2
618-46-2
403-43-0
122-01-0
1710-98-1
108-03-2
104-93-8
23159-07-1
3082-62-0