Propionyl Chloride 丙酰氯(易涉毒)

CAS 79-03-8 MFCD00000745

化学结构图

79-03-8
SMILES: CCC(=O)Cl

化学属性

Mol. FormulaC3H5ClO
Mol. Weight92.52
Density1.059
Refractive index1.4020 to 1.4060
Flash Point11.67°C
TSCAYes
Boiling Point77-79
Melting Point-94
Vapor Density3.2 (vs air)
Solubility起反应
Stability对湿度敏感
Danger-Level甲类
pH:A

别名和识别编码

Chemical NamePropionyl Chloride
Synonym Propionyl Chloride {LY} Propionyl Chloride Propionyl chloride Propanoyl chloride Propionylchlorid Propionylchloride,98% propionyl propionyl chloride {} {LY} Propionyl Chloride {} {} {LY} Propionyl Chloride {} {} {} {LY} Propionyl Chloride {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propionyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number79-03-8
EC Number201-170-0
Beilstein Registry Number385632
MDL NumberMFCD00000745
Merck Number7828
PubChem Substance ID87574699
Reaxys-RN385632
Chemical Name Translation丙酰氯(易涉毒)
LabNetwork Molecule IDLN00223335
Canonical SMILESCCC(Cl)=O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体
  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • 在有机合成中用作丙酰化试剂,是制备各种丙酸衍生物的中间体,如苯丙酮等;用于生产农药敌稗;医药工业用于生产抗癲痫药颠甲妥因;利胆醇;抗肾上腺素药甲氧胺盐酸盐等。

相关文献及参考

  • Short: II/25C
  • Short: II/27B
  • Merck: 14,7828
  • Short: II/14a
  • Merck: 14,7828 Beilstein:2(4)724

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R14 Reacts violently with water 遇水会猛烈反应
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupII
UN Number 1815
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room te
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3 F,C
Hazard Class3/8
RTECSUC3926000
Warnings 危化品目录(2015) 危险化学品

其他信息

  • 下游产品:苯丙酮 --> 丙酸酐 --> 萘丙胺 --> S-碘化丙酰硫代胆碱 --> 咪达普利 --> 3-氯丙酰氯 --> 硫普罗宁 --> 敌稗 --> 6-[2-(4-甲氧基苯基)-1H-苯并咪唑-5-基]-5-甲基-4,5-二氢-3(2H)-哒嗪酮 --> 泼尼卡酯 --> 罗他霉素 --> 1-(2,5-二甲氧基苯基)-1,2-丙二酮-2-肟 --> N-(2-羟基乙基)-2-[4-(2-甲基丙基)苯基]丙酰胺 --> 烯草酮 --> 敌草胺 --> 高效高分子酰化催化剂 --> N,N'-双[3-(3,5-二叔丁基-4-羟基苯基)丙酰]肼 --> 4-叔丁基苯丙酮 --> 丁酰乙酸乙酯 --> 2-甲氧基-6-丙酰基萘 --> 1-戊烯-3-酮 --> 6-甲氧基-Α-甲基-2-萘乙酸乙酯
  • 凝固点:-94℃
  • Sigma Aldrich:79-03-8(sigmaaldrich)
  • 用途二:用作烷基化试剂
  • Acros Organics:丙酰氯 Propionyl chloride, 98%(79-03-8)
  • 用途四:在有机合成中用作丙酰化试剂,是制备各种丙酸衍生物的中间体,如苯丙酮等;用于生产农药敌稗;医药工业用于生产抗癲痫药颠甲妥因、利胆醇、抗肾上腺素药甲氧胺盐酸盐等。
  • MOL 文件:79-03-8.mol
  • 方法二:丙酸与三氯化磷、五氯化磷、氯化亚砜或光气反应都可制丙酰氯。1.将丙酸与三氯化磷投入反应锅,加入数粒磁片,在50℃回流反应6h。静置1-2h,分去下层亚磷酸,即得丙酰氯。在丙酸:PCl3为1.32:1条件下,收率95%。所得粗品需提纯时,可采用蒸馏的方法,收集80℃左右馏分即得成品。原料消耗定额:丙酸(99.5%)990kg/t、三氯化磷(98%)690kg/t。2.苯甲酰氯法由丙酸与苯甲酰氯作用而得。
  • 常规方法:包装应密闭、防热、防潮。一般作中间体自用。按有毒化学品规定贮运。
  • 防护措施:有强烈的毒性和刺激性,极强地刺激皮肤和粘膜,甚至引起灼伤。遇水分解,产生出氯化氢。生产设备应密闭,现场要有好的通风条件。操作人员要穿戴好劳保用品。
  • 海关编码:29399990
  • 用途一:医药工业用于生产抗癫痫药甲妥因,抗肾上腺素药甲氧胺盐酸盐,在有机合成中用作丙酰试剂
  • TCI Shanghai:丙酰氯 Propionyl Chloride,>;98.0%(GC)(T)(79-03-8)
  • 用途三:丙酰氯是植物生长调节剂调环酸的中间体。
  • 外观性质:无色到浅黄色液体,有强烈刺激性气味。
  • 方法一:其制备方法是以丙酸与三氯化磷在40~50℃反应1h,冷却,静置,分离,精馏得产品。反应方程式:CH 3 CH 2 COOH+PCl 3 →CH 3 CH 2 COCl+HOPCl 2
  • 有刺激性气味。能溶于乙醚、氯仿、冰醋、酸、苯和汽油,遇水或乙醇剧烈地分解成丙酸、丙酸乙脂和氯化氢。
  • 图谱信息:丙酰氯(79-03-8)核磁图( 1 HNMR) 丙酰氯(79-03-8)质谱(MS) 丙酰氯(79-03-8)核磁图( 13 CNMR) 丙酰氯(79-03-8)红外图谱(IR1)
  • Alfa Aesar:丙酰氯,98% Propionyl chloride, 98%(79-03-8)
  • 上游原料:五氯化磷 --> 苯甲酰氯 --> 丙酸
  • 丙酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80108860 丙酰氯;氯化丙酰 100ml 37.7元 2011/08/23 80108826 丙酰氯;氯化丙酰 100ml 37.7元 2011/04/16 P0516 丙酰氯 Propionyl Chloride 500G 480元
  • 蒸气密度:3.2 (vs air)
  • 敏感性:Moisture Sensitive
  • MSDS 信息:丙酰氯(79-03-8).msds

系列性分类