3-Chloro-2-methylpropene 3-氯-2-甲基丙烯

CAS 563-47-3 MFCD00000953

化学结构图

563-47-3
SMILES: C=C(C)CCl

化学属性

Mol. FormulaC4H7Cl
Mol. Weight91
Density0.925
Refractive index1.4260 to 1.4280
Autoignition Point899 °F
Vapor Density3.12 (vs air)
Boiling Point73°C
Vapor Pressure102 mmHg ( 20 °C)
Melting Point-80
Flash Point-12°C
TSCAYes
Solubility微溶于水。

别名和识别编码

Chemical Name3-Chloro-2-methylpropene
Synonym {uni_hamburg} {Chem NCI-C54820 Methylallyl chloride isobutenyl chloride 2-Methyl-2-propenyl chloride 1-Chloro-2-methyl-2-propene 氯化异丁烯 3-chloro-2-methylpropene 2-Methallyl chloride methallyl chloride 3-氯-2-甲基-1-丙烯(MAC) {hazard_co {Chemi γ-Chloroisobutylene {uni_hambu methylallyl chloride 2-甲基烯丙基氯 3-CHLORO-2-METHYLPROPENE 3-Chlorisobutylen 2-Methylallyl chloride 3-Chloroisobutylene 甲代烯丙基氯 3-chloro-2-methylprop-2-en 异丁烯基氯 2-(Chloromethyl)-1-propene 1-氯-2-甲基-2-丙烯 3-chloro-2-methyl-propene 2-Methyl-3-chloro-1-propene β-Methallyl c Γ-氯异丁烯
CAS Number563-47-3
EC Number209-251-2
Beilstein Registry Number1,209
MDL NumberMFCD00000953
PubChem Substance ID87565372
Merck Number2148
Reaxys-RN878160
Chemical Name Translation3-氯-2-甲基丙烯
Wiswesser Line NotationG1Y1&U1
LabNetwork Molecule IDLN00224131
InChIInChI=1S/C4H7Cl/c1-4(2)3-5/h1,3H2,2H3
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分类

  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Alkenyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks

产品应用

  • 用作杀虫剂、塑料、药品等的中间体。

相关文献及参考

  • Short: II/25C
  • Short: III/20a
  • Merck:14,2148
  • Merck:14,2148 Beilstein:1,209

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S29 Do not empty into drains 不要排入下水道；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R34 Causes burns 会导致灼伤
  • R51/53
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R11 Highly flammable 非常易燃
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H332
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H332 Harmful if inhaled 吸入有害
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUC8050000
Packing GroupII
UN Number 2554
Hazard Codes 3
Hazard Class3
Storage condition Refrigerator (+4°C) + Flammables area
Warnings 危化品目录(2015) 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 77250 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51500 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38625 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 26,95,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51500 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 26,95,1985

TYPE OF TES

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3160 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - other changes
   Blood - changes in spleen
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 gm/m3/30M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAVUAI Fiziologicheski Aktivnye Veshchestva.  Physiologically Active
   Substances.  (Izdatel'stvo Naukova Dumka, Kiev, USSR)  No.1-    1966-
   Volume(issue)/page/year: 7,35,1975

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 22000 ppm/10M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,377,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 848 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539687

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 23200 ug/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4500 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   20,263,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 16 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,133,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 6 umol/plate
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   29,2611,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research

Restrict 危险品

其他信息

  • Acros Organics:3-氯-2-甲基丙烯 3-Chloro-2-methylpropene, tech., 90%(563-47-3)
  • {
  • 上游原料:顺式十八碳-9-烯酸 --> 异丁烯
  • 毒性分级:中毒
  • 下游产品:克百威 --> 呋喃酚 --> 2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰氯 --> 2,2,4,6,7-五甲基苯并呋喃 --> 苯丁锡 --> 3-甲基-3-丁烯-1-醇 --> 双酚A二甲基丙烯酸酯 --> 邻(2-甲基烯丙氧基)苯酚 --> 1-氯-2-甲基-2-苯基丙烷 --> 甲基丙烯磺酸钠
  • 急性毒性:口服-大鼠 LD50: 848 毫克/公斤; 口服-小鼠 LDL0: 3160 毫克/公斤
  • 灭火剂:泡沫, 干粉, 二氧化碳, 砂土
  • Alfa Aesar:3-氯-2-甲基丙烯,98% 3-Chloro-2-methylpropene, 98%(563-47-3)
  • 用途一:用于合成杀螨锡、甲代烯丙基磺酸钠、3-氯-2-甲基环氧丙烷等
  • 外观性质:无色或淡黄色易挥发的液体, 有刺激性气味。
  • 用途二:2-甲基-3-氯丙烯又称甲代烯丙基氯，用于合成杀螨剂苯丁锡的中间体氯代叔丁基苯，也可用于合成杀虫剂克百威的中间体呋喃酚。
  • Sigma Aldrich:563-47-3(sigmaaldrich)
  • 蒸气密度:3.12 (vs air)
  • 职业标准:STEL 0.3 毫克/立方米
  • 用途三:该产品是一种重要的有机中间体，可广
  • 类别:易燃液体
  • 用途四:用作杀虫剂、塑料、药品等的中间体。
  • 方法一:2-甲基-3-氯丙烯是由异丁烯与液氯反应制得。 异丁烯和液氯经气化后分别计量，然后按合适配比通入反应器，反应强烈放热，须严格控制反应接触时间，并在瞬间混合均匀进行反应。反应后物料进入反应蒸发器，移除反应热，再进入吸收冷凝器，将氯化氢吸收成盐酸，然后经冷却、油酸分离，盐酸可作为副产出售，有机层经分馏得到2-甲基-3-氯丙烯，含量可达95%～98%。
  • 图谱信息:3-氯-2-甲基丙烯(563-47-3)核磁图( 1 HNMR) 3-氯-2-甲基丙烯(563-47-3)Raman光谱 3-氯-2-甲基丙烯(563-47-3)质谱(MS) 3-氯-2-甲基丙烯(563-47-3)红外图谱(IR1) 3-氯-2-甲基丙烯(563-47-3)核磁图( 13 CNMR)
  • TCI Shanghai:3-氯-2-甲基-
  • 可燃性危险特性:易燃; 受热分解有毒氯化物气体
  • 3-氯-2-甲基丙烯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0209 3-氯-2-甲基-1-丙烯 3-Chlo
  • MOL 文件:563-47-3.mol
  • {Chemicalbo
  • 有刺激性气味，微
  • 爆炸物危险特性:与空气混合形成爆炸性混合物;
  • 蒸气压:102 mm Hg ( 20 °C)
  • MSDS 信息:1-氯-2-甲基-2-丙烯(563-47-3).msds
  • 海关编码:29032900
  • 用途三:该产品是一种重要的有机中间体，可广泛用于医药、农药、香料、合成材料等领域。
  • 3-氯-2-甲基丙烯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0209 3-氯-2-甲基-1-丙烯 3-Chloro-2-methyl-1-propene 25ML 104元 2014/06/02 C0209 3-氯-2-甲基-1-丙烯 3-Chloro-2-methyl-1-propene 500ML 279元 2010/06/21 148420500 3-氯-2-甲基丙烯 3-Chloro-2-methylpropene 90%, tec

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkyl 烷基卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkenyl - Halogenated Hydrocarbons

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