1,2-Dihydroxybenzene 1,2-二羟基苯

CAS 120-80-9 MFCD00002188

化学结构图

120-80-9
SMILES: OC1CCCCC1O

化学属性

Mol. FormulaC6H6O2
Mol. Weight110
Boiling Point245
Melting Point103-106
Density1.370
Flash Point127°(260°F)
TSCAYes
Vapor Density3.8 (vs air)
Vapor Pressure1 mmHg ( 75 °C)
Solubility430 G/L (20 ºC)
Stability空气敏感，光敏感

别名和识别编码

Chemical Name1,2-Dihydroxybenzene
CAS Number120-80-9
Synonym 1 1, 1,2-Benzene 1,2-Benzenediol, Pyr 1,2-Benzenediol,Pyrocatechol 1,2-Dihydroxybenzene 1,2-二羟基苯 2-二羟基苯 o-Dihydroxy-benzol o-Hydroxyphenol o-Phenylenediol AKOS BBS Benzene, o-dihydroxy- Brenzcatechin Brenzkatechin C.I. 76500 CW-C 2 Durafur Developer C NCI-C55856 PYROCATECHIN Pelagol Grey C Phthalhydroquinone Pyrocatechin Pyrocatechine Pyrocatechuic acid Pyrocatecol Pyrokatechin benzene-1,2-diol o-Benzenediol o-Dihydroxybenzene {} {} { {} {} {ALD} {} {} {Chemicalb {} {} {uni_ha 兒茶酸 焦性儿茶酚,儿茶酚,1,2-二羟基苯,1,2-苯二酚 邻苯二酚 邻苯二酚(儿茶酚)
PubChem Substance ID289
EC Number204-427-5
Beilstein Registry Number471401
MDL NumberMFCD00002188
Reaxys-RN471401
Merck Number7999
Chemical Name Translation1,2-二羟基苯
Wiswesser Line NotationQR BQ
LabNetwork Molecule IDLN00194374
InChIInChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H
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分类

  • {SNA} A to C, Acacia, Adenylate cyclase, Allium cepa (Onion), Amino Acid,
  • {SNA} A to
  • {SNA} Acacia, Allium cepa (Onion), Cichorium intybus (Chicory), Ginkgo biloba, Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 氨基甲酸酯类杀菌剂
  • {SNA} A to C,

产品应用

  • 显色反应或比色分析测定钛、钼、钨、钒、铁和铈。

相关文献及参考

  • In the presence of catechol, carboxylic acids are reduced to alcohols by NaBH4: Tetrahedron, 48, 371 (1992).
  • Merck: 14,7999
  • Short: II/19b
  • Merck: 14,7999 Beilstein: 6,IV,5557
  • Ring-opening with O2 in the presence of CuCl, pyridine and methanol gives the monoester of cis,cis-muconic acid: Org. Synth. Coll., 8, 490 (1993).
  • For an example of the use of catechol in the synthesis of crown ethers, see: Org. Synth. Coll., 6, 395 (1988).

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H301+H311
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 Xn
RTECSUX1050000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P312
  • P305+P351+P338
  • P305+P351+P338+P310
  • P332+P313
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
UN Number 2811 UN 2811 6.1/PG 3
Packing GroupII
Storage condition 充氩储存 Store at RT. 密封干燥避光保存。 Air & Light Sensitive
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 349 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   33,93,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 171 gm/kg/51W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 85,17,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 437 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 81,207,1990

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60640 mg/kg/24W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 77,854,1986

{haza

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 176,193,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 166,437,1932

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 15,136,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVE

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MOPMA3 Molecular Pharmacology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1965-  Volume(issue)/page/year: 28,560,1985

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 373,113,1997

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 500 mg/L
REFERENCE :
   ESKGA2 Eisei Kagaku.  Hygienic Chemistry.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1-    1953-
   Volume(issue)/page/year: 32,171,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Cyt

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rabbit Bone marrow
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AJIMD8 American Journal of Industrial Medicine.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.1-    1980-  Volume(issue)/page/year:
   7,485,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 4 ug/plate
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo Internatio

{hazar

TYPE O

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   57,466,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 41,43,1990

Restrict 危险品

其他信息

  • 爆炸物危险特性:与氧化剂反应剧烈
  • 用途四:作为重要的医药中间体，用来制造黄连素和异丙肾上腺素等。也可用于生产4-叔丁基邻苯二酚，作苯乙烯、丁二烯、氯乙烯的阻聚剂。或用于制造抗氧
  • 用途三:邻苯二酚是杀菌剂乙霉威、杀虫剂残杀威和克百威的中间体。
  • Alfa Aesar:邻苯二酚,99% Catechol, 99%(120-80-9)
  • Acros Organics:邻苯二酚/儿茶酚 Catechol, 99+%(120-80-9)
  • 溶于2.3倍的水，溶于乙醇、苯、氯仿、乙醚，易溶于吡啶和苛性碱液。 邻苯二酚有毒，可燃；遇空气和光变色。其溶液在空气中变为棕褐色。能升华。能随水蒸气挥发。水溶液很快变成褐色，能还原硝酸银氨溶液和斐林氏溶液。有毒，半数致死量(小鼠，经口)260mg/kg。有刺激性。
  • 外
  • 下游产品:1,4-苯二酚 --> 克百威 --> 乙基香兰素 --> 胡椒醛 --> 残杀威 --> 呋喃酚 --> 4-甲酰-15-冠-5 --> 1,2-亚甲二氧基苯 --> 万霉灵 --> 2-(5-溴-2-吡啶偶氮)-5-二乙氨基酚 --> 邻苯二甲醚 --> 2,3-二氢-1,4-苯并二恶烷-2-羰酰氯 --> 对叔丁基邻苯二酚 --> 1-溴环戊-1-烯 --> 四溴邻苯醌 --> 1,3-苯并二氧杂环戊烯-5-乙腈 --> 苯并-15-冠醚-5 --> 邻苯二乙醚 --> 2-异丙氧基苯酚 --> 邻(2-甲基烯丙氧基)苯酚 --> 1,3-苯并二氧-5-磺酰氯 --> 2-羟甲基-1,4-苯并二噁烷对甲苯磺酸酯 --> 3,4-二羟基-2'-氯苯乙酮 --> 儿萘酚硼烷 --> 胡椒基氯 --> 2-(烯丙氧基)苯酚 --> 2-羟基甲基-1,4-苯二恶 --> 1-碘庚烷 --> 儿茶酚紫 --> 肾上腺酮 -->
  • 蒸气压:1 mm Hg ( 75 °C)
  • 邻苯二酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80030826 邻苯二酚;焦性儿茶酚; 儿茶酚; 1,2-二羟基苯 100g
  • MSDS 信
  • 蒸气密度:3.
  • 下游产品:1,4-苯二酚 --> 克百威 --> 乙基香兰素 --> 胡椒醛 --> 残杀威 --> 呋喃酚 --> 4-甲酰-15-冠-5 --> 1,2-亚甲二氧基苯 --> 万霉灵 --> 2-(5-溴-2-吡啶偶氮)-5-二乙氨基酚 --> 邻苯二甲醚 --> 2,3-二氢-1,4-苯并二恶烷-2-羰酰氯 --> 对叔丁基邻苯二酚 --> 1-溴环戊-1-烯 --> 四溴邻苯醌 --> 1,3-苯并二氧杂环戊烯-5-乙腈 --> 苯并-15-冠醚-5 --> 邻苯二乙醚 --> 2-异丙氧基苯酚 --> 邻(2-甲基烯丙氧基)苯酚 --> 1,3-苯并二氧-5-磺酰氯 --> 2-羟甲基-1,4-苯并二噁烷对甲苯磺酸酯 --> 3,4-二羟基-2'-氯苯乙酮 --> 儿萘酚硼烷 --> 胡椒基氯 --> 2-(烯丙氧基)苯酚 --> 2-羟基甲基-1,4-苯二恶 --> 1-碘庚烷 --> 儿茶酚紫 --> 肾上腺酮 --> 4-溴邻苯二酚 --> 异丙肾上腺素
  • 用途五:显色反应或比色分析测定钛、钼、钨、钒、铁和铈。
  • 图谱信息:邻苯二酚(120-80-9)红外图谱(IR1) 邻苯二酚(120-80-9)质谱(MS)
  • 防护措施:有毒。对中枢神经、呼吸系统有刺激作用。大鼠经口LD50为3890mg/kg。与间苯二酚及对苯二酚不同。本品毒性不大。吸入小量本品，可以在体内形成有机硫酸盐而解毒，随尿排出体外。生产设备应注意密闭，操作人员配戴防护用具。
  • 图谱信息:邻苯二酚(120-80-9)红外图
  • 外观性质:无色结晶，见光或露置空气中变色，能升华。
  • 急性毒性:口服-大鼠LD50: 260 毫克/公斤; 口服-小鼠LD50: 260 毫克/公斤
  • 常规方法:采用25～180kg的铁桶包装。按一般可燃化学品规定贮运。
  • 灭火剂:雾状水、二氧化碳、砂土

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Ginkgo biloba - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Protected Alcohols/Phenols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Polyols - Oxygen Compounds
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Adenylate cyclase - A to C
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Adenosinetriphosphatase (microsomal calcium)
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Protein phosphatase-1, Catalytic Subunit
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)